Evidence map›Paper›PMID 31149350›Full record

ArticleNPJ vaccines2019

The TLR4 agonist adjuvant SLA-SE promotes functional mucosal antibodies against a parenterally delivered ETEC vaccine.

Hong Liang, David Poncet, Emilie Seydoux, Nicholas D Rintala, Milton Maciel, Sophie Ruiz, Mark T Orr

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Design of a Novel Peptide-Based Vaccine TargetingInternational journal of dentistry · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Mechanisms of uropathogenicScience advances · 2025
    Article
  10. Immunogenicity and safety of anHuman vaccines & immunotherapeutics · 2024
    Article
  11. Article
  12. Recent advances in enterotoxin vaccine adjuvants.Current opinion in immunology · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hong Liang1Infectious Disease Research Institute, Seattle, WA USA.
David Poncet2Sanofi Pasteur, Marcy l'Etoile, France.
Emilie Seydoux1Infectious Disease Research Institute, Seattle, WA USA.
Nicholas D Rintala1Infectious Disease Research Institute, Seattle, WA USA.
Milton Maciel3Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD USA.
Sophie Ruiz2Sanofi Pasteur, Marcy l'Etoile, France.
Mark T Orr1Infectious Disease Research Institute, Seattle, WA USA.ORCID 0000-0003-2684-4722
Infectious Disease Research Institute · USInstitut Pasteur · FRHenry M. Jackson Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many pathogens establish infection at mucosal surfaces such as the enteric pathogen

Indexed as

AdjuvantsGastrointestinal systemVaccines

Identifiers

PMID31149350
PMCPMC6538625
OpenAlexW2947381190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.