ArticleActa endocrinologica (Bucharest, Romania : 2005)
CRANIOPHARYNGIOMA - CLINICAL AND THERAPEUTIC OUTCOME DATA IN A MIXED COHORT OF ADULT AND PAEDIATRIC CASES.
Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Global pediatric craniopharyngioma management modalities and outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Association of histological subtype with risk of recurrence in craniopharyngioma patients: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- Visual functions in children with craniopharyngioma at diagnosis: A systematic review.PloS one · 2020Pooled it
- Virtual Reality and Three-Dimensional Printing of Craniopharyngioma: A Case Report Proposing an Innovative Model of Pediatric Endocrine Care to Enhance Patient Engagement.Clinical case reports · 2025Article
- Editorial: Advances and challenges in adult-onset craniopharyngioma.Frontiers in endocrinology · 2025Article
- A case-based review of adult-onset craniopharyngioma.Frontiers in endocrinology · 2025Review
- Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy.Reviews in endocrine & metabolic disorders · 2024Review
- Serum sodium level fluctuations following the resection of childhood-onset craniopharyngioma.Brain and behavior · 2024Article
- Risk Factor and Replacement Therapy Analysis of Pre- and Postoperative Endocrine Deficiencies for Craniopharyngioma.Cancers · 2023Article
- Postoperative hypothalamic-pituitary dysfunction and long-term hormone replacement in patients with childhood-onset craniopharyngioma.Frontiers in endocrinology · 2023Article
- Multidisciplinary Management of Craniopharyngiomas in Children: A Single Center Experience.Diagnostics (Basel, Switzerland) · 2022Article
- Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits.Neuroscience and biobehavioral reviews · 2022Review
- Adamantinomatous Craniopharyngioma in an Adult: A Case Report with NGS Analysis.International medical case reports journal · 2020Article
- Recurrent Urinary Tract Infection in Craniopharyngioma: A Harbinger to a Sinister Diagnosis!Journal of pediatric neurosciencesArticle
- Craniopharyngiomas in children - experience of consecutive 152 operated cases.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCraniopharyngiomas are benign but locally invasive tumours of the sellar region that arise from ectopic embryonic remnants of Rathke's pouch, affecting both children (adamantinomatous type -aCP) and adults (papillary type -pCP) and associated with significant morbidity.
objectiveTo study the clinical presentation of CRF as well as the posttreatment evolution of craniopharyngioma in children MATERIAL AND
methodsWe performed a retrospective review of CRF patients evaluated in the National Institute of Endocrinology in Bucharest between 1990 and 2016.
resultsA total of 107 patients (72 adults, 35 children) with a mean follow-up of 6.2 years were included. The presenting symptoms were mostly headache, visual impairment, symptoms of hypopituitarism, diabetes insipidus. Some symptoms or hormonal abnormalities were significantly more prevalent in the children group (p<0.05): nausea/ vomiting (47.8% vs 16.7%), photophobia (21.7% vs 5.6%), diabetes insipidus(28.5% vs 8.3%), GH deficiency (68.8% vs 17.1%). Impaired visual acuity (67.6%of cases) or visual fields (71.4%) were more frequent in adults compared to children (44.1%; 51.6%). The tumor dimensions were similar in both groups (3.05± 1.05 cm in children; 2.7± 1.07 cm in adults). Massive suprasellar extension reaching the third ventricle was frequently present in all cases. All cases underwent surgery but only a minority of those not cured received postoperative adjuvant radiotherapy. Frequent postoperative complications were: aggravation of the endocrine deficit (>80% of cases in both groups needed chronic replacement therapy), central diabetes insipidus (68.2% children, 34.3% of adults).
conclusionsDespite similar tumor dimensions and extension compared to adults, craniopharyngioma in children is more frequently associated with signs of intracranial pressure. The results and complications of treatment are similar in adults and children.
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