ArticleActa endocrinologica (Bucharest, Romania : 2005)
CHRONIC UNPREDICTABLE MILD STRESS PROGRESSIVELY DISTURBS GLUCOSE METABOLISM AND APPETITE HORMONES IN RATS.
Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs.The international journal of neuropsychopharmacology · 2026Article
- Oral Administration of Bovine Lactoferrin Modulates the Effects of Chronic Stress on the Immune Response of the Lungs.International journal of molecular sciences · 2025Article
- Protective Effects ofLife (Basel, Switzerland) · 2025Article
- Long-Term Effects of Stress During Adolescence on the Sex-Dependent Responses of Thyroid Axis and Target Tissues to Exercise in Male and Female Wistar Rats.International journal of molecular sciences · 2025Article
- Modulating depressive-like behaviors, memory impairment, and oxidative stress in chronic stress rat model using visible light therapy.Scientific reports · 2025Article
- Alamandine enhanced spatial memory in rats by reducing neuroinflammation and altering BDNF levels in the hippocampus and prefrontal cortex.Scientific reports · 2025Article
- Psychological dominant stressor modification to an animal model of depression with chronic unpredictable mild stress.Veterinary world · 2023Article
- Effects of Aqueous Saffron Extract on Glucoregulation as Well as Hepatic Agt and TNF-α Gene Expression in Rats Subjected to Sub-Chronic Stress.Advanced biomedical research · 2023Article
- Protective effects of ThaiJournal of traditional and complementary medicine · 2022Article
- Effect of aflatoxin B1 exposure on the progression of depressive-like behavior in rats.Frontiers in nutrition · 2022Article
- Dopamine receptor activation elicits a possible stress-related coping behavior in a wild-caught songbird.PeerJ · 2022Article
- Cellular senescence as a driver of cognitive decline triggered by chronic unpredictable stress.Neurobiology of stress · 2021Article
- Transthyretin as a Biomarker to Predict and Monitor Major Depressive Disorder Identified by Whole-Genome Transcriptomic Analysis in Mouse Models.Biomedicines · 2021Article
- The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders.Frontiers in synaptic neuroscience · 2020Review
- AMELIORATIVE EFFECT OF VORTIOXETINE IN EXPERIMENTAL MODEL OF ENDOCRINE PANCREAS DAMAGE RELATED TO CHRONIC UNPREDICTABLE MILD STRESS: AN IMMUNOHISTOCHEMICAL STUDY.Acta endocrinologica (Bucharest, Romania : 2005)Article
- 18F-FLUORODEOXYGLUCOSE PET/CT CAN BE AN ALTERNATIVE METHOD TO ASSESSMENT OF INSULIN RESISTANCE.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextChronic stress is characterized by increased release of catecholamines, glucocorticoids and other neurohumoral factors, predisposing individuals to obesity, insulin resistance and vascular disease, pathologies considered priority health problems. Study of alterations induced by stress on metabolism in association with food intake modulatory hormones (insulin, leptin and ghrelin) is mandatory.
objectiveThis research studied temporal course during 60 days of chronic unpredictable mild stress (CUMS) on glucose and lipids metabolism, and on the neuroendocrine system that regulates appetite-satiety balance. MATERIALS AND
methodsWistar rats were exposed to CUMS for 20, 40 and 60 days. Corticosterone stayed high during 60 days of CUMS; after 40 days, body weight, cholesterol and triglycerides decreased and glucose intolerance was evident at day 60; insulin and ghrelin increased at 20 and 40 days, respectively; leptin decreased after day 20. Data suggest that 60 days of CUMS progressively disturb metabolism of carbohydrates and lipids as well as food intake regulatory hormones, affecting the metabolism, and can lead to the development of chronic degenerative diseases, such as cardiovascular disease, metabolic syndrome and type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.