ArticleActa endocrinologica (Bucharest, Romania : 2005)
GESTATIONAL DIABETES MELLITUS AND THE DEVELOPMENT OF CLEFT LIP / PALATE IN NEWBORNS.
Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 27 citations in OpenAlex.
- Adverse events during pregnancy, circulating metabolites, and congenital malformations: a Mendelian randomization study.BMC pregnancy and childbirth · 2025Article
- Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review.Children (Basel, Switzerland) · 2024Article
- Single visit rehabilitation of 12-day neonate with cleft palate using modified feeding spoon impression technique: A case report.Clinical case reports · 2023Article
- Knowledge regarding teratogens among women of childbearing age at a large tertiary care center in Saudi Arabia.Journal of family medicine and primary care · 2020Article
- Validation of Thymocyte Selection-associated High-mobility Group Box-3 Gene Mutation and Risk Identification in Non-syndromic Cleft Lip and Palate Deformities in Malay Patients - A Retrospective Study.Annals of maxillofacial surgeryArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundSeveral studies observed metabolic disorders in pregnancy as risk factors for birth defects, including orofacial clefts. Diabetes is associated with approx. 10% of the pregnancies, but in Romania, less than 5%. An obese and diabetic woman has 3 times more risk for an offspring with a craniofacial defect than healthy women suggesting that diabetes mellitus contributes to their pathogenesis with complex mechanisms. CASE REPORT: We present the case of a newborn 4 days old, male with neonatal hypoglycemia, cleft lip and proportionate (symmetric) macrosomia. His mother is a 35 years old Caucasian woman with no important personal risk factors and no known history of diabetes mellitus. The glucose tolerance test performed to the mother at about 10 weeks during pregnancy led to the diagnosis of gestational diabetes. DISCUSSION: The gestational diabetes mellitus diagnosed since the 10
conclusionWith the increased prevalence of obesity, diabetes, and the evidence of association of these syndromes with OFCs, it is recommended that mothers planning to become pregnant to follow healthy habits, maintain healthy weight, and be screened for possible diabetes prior to conception and early in pregnancy.
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