Evidence map›Paper›PMID 31148989›Full record

ArticleAfrican health sciences2019

Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus.

Tuba T Duman, Gulali Aktas, Burcin M Atak, Mehmet Z Kocak, Edip Erkus, Haluk Savli

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Article in African health sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in retinal artery occlusion: a meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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  17. Evaluation of Hematological Parameters in Diabetic Patients.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025
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  18. Inflammation, diabetic foot and related treatments.Frontiers in endocrinology · 2025
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tuba T DumanAbant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.
Gulali AktasAbant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.
Burcin M AtakAbant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.
Mehmet Z KocakAbant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.
Edip ErkusAbant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.
Haluk SavliAbant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus is associated with chronic low grade inflammation. One of the novel inflammatory markers is hemogram derived neutrophil to lymphocyte ratio (NLR).

objectiveWe aimed to compare NLR levels of diabetic subjects and healthy controls and to observe possible correlation between NLR and HbA1c.

methodsMedical data of type 2 diabetic subjects admitted to out-patient clinics of our institution between April to July in 2017 were obtained from database and retrospectively analyzed. Control group was chosen from healthy subjects who visited our institution for a routine check-up. Anthropometric measures, laboratory data, including, HbA1c, NLR were recorded.

resultsMedian NLR of the type 2 DM group 2.44 (1.9) was significantly elevated when compared to healthy controls (1.5 (0.9), (p<0.001). In addition, a Pearson's correlation test revealed that NLR was strongly correlated with age (r=0.26, p=0.008), fasting plasma glucose (r=0.38, p<0.001), and HbA1c (r=0.49, p<0.001).

conclusionElevated NLR in otherwise healthy subjects may be indicative of underlying impaired glucose metabolism and moreover, NLR should be used as a marker of diabetic control level in addition to HbA1c in type 2 diabetic subjects.

Indexed as

AdolescentAdultBiomarkersBody Mass IndexCase-Control StudiesDiabetes Mellitus, Type 2FemaleGlucose IntoleranceGlycated HemoglobinHumansInflammationLymphocyte CountLymphocytesMaleMiddle AgedNeutrophilsBiomarkersGlycated HemoglobinHbA1cinflammationneutrophil to lymphocyte ratioType 2 diabetes mellitus

Identifiers

PMID31148989
PMCPMC6531946

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.