SynthesisAfrican health sciences2019
IL-18 polymorphisms and tuberculosis susceptibility: a meta-analysis.
Synthesis in African health sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: A meta-analysis.African health sciences · 2023Pooled it
- Association between interleukin-8 -251A/T polymorphism and the risk of tuberculosis: A meta-analysis.The Journal of international medical research · 2020Pooled it
- Impact of genetic polymorphisms in the interleukin-18 and interleukin-21 genes on the risk and clinical outcomes of multiple sclerosis.BMC neurology · 2026Article
- The role of TGF-β1 C-509T and TGF-β1 T869C polymorphisms in susceptibility to tuberculosis infection in a Sudanese population: a case-control study.BMC infectious diseases · 2025Article
- The role of IFN-γ + 874T/A and IL-12 + 16974A/C polymorphisms in susceptibility to tuberculosis infection in a Sudanese population: a case-control study.BMC infectious diseases · 2025Article
- Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis.PloS one · 2021Article
- Infections, NCDS, and the scourge of cyclones and Ebola in sub-Saharan Africa.African health sciences · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between IL-18 polymorphisms and Tuberculosis(TB). MATERIALS AND
methodsWe searched PubMed and Embase databases, and conducted a meta-analysis using 4 models. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using STATA 12.0 software.
resultsFive qualified studies with a total of 1293 TB patients and 1724 controls were included. There was no significant association between the IL-18 -607C>A polymorphism and TB risk in the total population(AA vs CC: OR=1.27,95% CI=0.82-1.96;-CA vs CC:OR=1.06,95% CI=0.89-1.26; Dominant model: OR =1.09, 95% CI =0.83-1.43; Recessive model:OR=1.23, 95% CI=0.92-1.65). For IL-18 -137G>C polymorphism, lack of an association was also found(GG vs CC: OR=1.42,95% CI=0.78-2.58;GC vs CC:OR=1.16,95% CI=0.62-2.16; Dominant model: OR =1.34,95% CI=0.74-2.43;Recessive model:OR=0.96,95%-CI=0.26-3.56).
conclusionThe present meta-analysis found no evidence for IL-18 -607C>A and -137G>C polymorphisms as risk factors for TB. Further large-scale and well-designed articles are still needed to validate this result.
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