ArticleMediators of inflammation2019
The Relationship between Serum Bilirubin and Inflammatory Bowel Disease.
Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- The Causal Association between Total Bilirubin, Direct Bilirubin, and Ulcerative Colitis: A Two-Sample Mendelian Randomization Study.Cell biochemistry and biophysics · 2025Article
- Relationship between serum total bilirubin levels and primary loss of response to Infliximab therapy in Crohn's disease patients.BMC gastroenterology · 2025Article
- Bilirubin - new insights into an old molecule.Biochemia medica · 2025Review
- Early predictors of induction of remission with exclusive enteral nutrition in children with Crohn's disease.BMC pediatrics · 2025Article
- Lymphocyte levels in Crohn's disease patients in clinical remission are significantly lower than those in healthy people.European journal of medical research · 2025Article
- Bilirubin metabolism in relation to cancer.Frontiers in oncology · 2025Review
- Changes in Serum Bilirubin and Total Bile Acids During Biologic Therapy in Patients with Ulcerative Colitis: A Retrospective Study.Journal of inflammation research · 2025Article
- Article
- C-reactive protein-to-albumin ratio and neutrophil-to-albumin ratio for predicting response and prognosis to infliximab in ulcerative colitis.Frontiers in medicine · 2024Article
- BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen.Nature microbiology · 2024Article
- Clinical Utility of the Neutrophil-to-Bilirubin Ratio in the Detection of Disease Activity in Ulcerative Colitis.Journal of inflammation research · 2023Article
- Clinical significance of the C-reactive protein-to-bilirubin ratio in patients with ulcerative colitis.Frontiers in medicine · 2023Article
- High indirect bilirubin levels as an independent predictor of postoperative myasthenic crisis: a single-center, retrospective study.Frontiers in neurology · 2023Article
- Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid.Antioxidants (Basel, Switzerland) · 2022Article
- Blockade of PGK1 and ALDOA enhances bilirubin control of Th17 cells in Crohn's disease.Communications biology · 2022Article
- Association between lncRNAs in plasma exosomes and diabetic retinopathy.Frontiers in endocrinology · 2022Article
- Clinical Significance of Novel Neutrophil-Based Biomarkers in the Diagnosis and Prediction of Response to Infliximab Therapy in Crohn's Disease.Frontiers in immunology · 2022Article
- Effects of Jian Pi Qing Chang Hua Shi decoction on mucosal injuries in a 2,4,6-trinitrobenzene sulphonic acid-induced inflammatory bowel disease rat model.Pharmaceutical biology · 2021Article
- Association between serum bilirubin and mucosal healing among Japanese patients with ulcerative colitis: a cross-sectional study.International journal of colorectal disease · 2021Article
- Unconjugated Bilirubin Attenuates DSS-Induced Colitis PotentiallyFrontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The associations between serum total bilirubin (sTB) levels, inflammatory marker levels, and disease activity are not well understood in patients with inflammatory bowel disease (IBD). The present study investigated the association between sTB levels and disease activity in patients with IBD. We conducted a retrospective study with a total of 242 consecutive patients with Crohn's disease (CD) and 211 consecutive patients with ulcerative colitis (UC). The Crohn's Disease Activity Index (CDAI) score was used to assess disease activity in patients with CD and the Mayo score of patients with UC. 255 clinically healthy subjects comprised the control group, which come from the same geographic area as the IBD group. We retrieved the clinical and laboratory parameters of patients with IBD from the medical records. Patients with IBD displayed significantly lower sTB levels than controls. sTB levels were negatively associated with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fecal calprotectin (FC), and hemoglobin (Hb) levels in patients with IBD. Additionally, there was a negative association between sTB levels and the CDAI score of patients with CD. sTB levels were also negatively associated with the Mayo score of patients with UC. IBD patients had lower sTB levels when compared with controls, and there was a negative correlation between sTB levels and disease activity in patients with IBD. Increased reactive oxygen species production in IBD is likely to be responsible for increased consumption of bilirubin in patients with IBD, leading to further intestinal injury. Reducing oxidative stress may be therapeutic for these patients.
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