ArticleJournal of pharmacy & bioallied sciences
Screening of Potential Phytocompounds From
Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Screening, Docking, and Molecular Dynamics Study of Natural Compounds as an Anti-HER2 for the Management of Breast Cancer.Life (Basel, Switzerland) · 2022Article
- From laboratory to industrial storage - Translating volatile organic compounds into markers for assessing garlic storage quality.Postharvest biology and technology · 2022Article
- (5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate fromBioinorganic chemistry and applications · 2022Article
- Molecular docking and GC-MS data for the inhibition of RAD51 expression by a compound from Clerodendrum inerme L.Bioinformation · 2021Article
- Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells.Bioinformation · 2021Article
- MTT assay based inhibition analysis of A2780 cells proliferation usingBioinformation · 2021Article
- Anti-ovarian cancer potential of phytocompound and extract from South African medicinal plants and their role in the development of chemotherapeutic agents.American journal of cancer research · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOverexpression of human epidermal growth factor receptor 2 (HER2) plays an important role in the development and progression in a variety of cancers and it is a novel therapeutic target for breast cancer and ovarian cancer.
aimsThe aim of this study was to evaluate the potential inhibitors against HER2 from hexane extract of MATERIALS AND
methodsChemical fingerprinting method was used to identify the presence of natural compounds from the extract whereas their inhibitory activities were analyzed by molecular docking analysis against HER2. Absorption, distribution, metabolism, and excretion (ADME) properties also predicted to establish the pharmacokinetics and pharmacodynamics profiles of the selected compounds.
resultsThe molecular docking analysis expressed that phenyl glucuronide, hydrocortisone acetate, and 6-(4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-yl-amino)hexanoic acid trifluoroacetate possess good inhibitory activities with good glide score of -6.63, -5.41, and -5.40 and glide energy of -35.03, -42.51, and -31.38 kcal/mol, respectively when compared with standard Food and Drug Administration-approved drug and other compounds. All the screened compounds were within the acceptable and permissible limits of ADME properties.
conclusionThus, from this study it can be concluded that, these screened natural compounds from
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.