Evidence map›Paper›PMID 31148594›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2019

Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis, and gene expression in mouse colon tumorigenesis.

Jinyu Tang, Ying Feng, Rork Kuick, Megan Green, Maranne Green, Naoya Sakamoto, Yuki Kurosu, Jeffry Lin, Kathleen R Cho, Eric R Fearon

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. From Bench to Bedside: Emerging Paradigms in CAR-T Cell Therapy for Solid Malignancies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jinyu TangDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Ying FengDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Rork KuickDepartment of Biostatistics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-8817-5192
Megan GreenDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Maranne GreenDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Naoya SakamotoDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Yuki KurosuDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Jeffry LinDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Kathleen R ChoDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Eric R FearonDepartments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. fearon@umich.edu.
University of Michigan · USCentral South University · CNHiroshima University · JP

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
NCI NIH HHS P30 CA046592NIDDK NIH HHS P30 DK034933
6 · The paper itself

Abstract

Somatic APC (adenomatous polyposis coli), TP53, KRAS mutations are present in roughly 80%, 60%, and 40%, respectively, of human colorectal cancers (CRCs). Most TP53 mutant alleles in CRCs encode missense mutant proteins with loss-of-function (LOF) of p53's transcriptional activity and dominant negative (DN) effects on wild-type p53 function. Missense mutant p53 proteins have been reported to exert gain-of-function (GOF) effects in cancer. We compared the phenotypic effects of the common human cancer-associated TP53 R273H missense mutation to p53 null status in a genetically engineered mouse CRC model. Inactivation of one allele of Apc together with activation of a Kras mutant allele in mouse colon epithelium instigated development of serrated and hyperplastic epithelium and adenomas (AK mice). Addition of a Trp53

Indexed as

AdenocarcinomaAnimalsCarcinogenesisColorectal NeoplasmsDisease ProgressionEpithelial-Mesenchymal TransitionGene ExpressionHumansMice, TransgenicMutation, MissenseNeoplasm InvasivenessNeoplasm MetastasisTumor Suppressor Protein p53TP53 protein, humanTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID31148594
PMCPMC6759392
OpenAlexW2947193333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.