ArticleScientific reports2019
Physical Radiation Enhancement Effects Around Clinically Relevant Clusters of Nanoagents in Biological Systems.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Chemical vs Physical Radioenhancement from TiONano letters · 2025Trial
- Radiotherapy-activated NBTXR3 nanoparticles promote ferroptosis through induction of lysosomal membrane permeabilization.Journal of experimental & clinical cancer research : CR · 2024Article
- Application of nano-radiosensitizers in combination cancer therapy.Bioengineering & translational medicine · 2023Review
- Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles.Journal of applied clinical medical physics · 2023Review
- Advancements in the use of Auger electrons in science and medicine during the period 2015-2019.International journal of radiation biology · 2023Review
- Article
- Local Analysis of Heterogeneous Intracellular Transport: Slow and Fast Moving Endosomes.Entropy (Basel, Switzerland) · 2021Article
- Article
- Gold nanoparticle mediated radiation response among key cell components of the tumour microenvironment for the advancement of cancer nanotechnology.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we show that the determining factor for physical radiation enhancement effects for a clinically realistic cluster of heavy-atom bearing nanoparticles is the total number of heavy atoms packed into the cluster. We do this through a multiscale Monte Carlo approach which permits the consideration of radiation transport through clusters of millions of nanoparticles. The finding is in contrast to that predicted when isolated nanoparticles are considered and is a direct consequence of the Auger electrons playing less of a role for clusters compared to isolate nanoparticles. We further show that this result is agnostic to selection of the subcellular region considered to be sensitive to the effects of radiation, provided the inside the cluster of nanoparticles is not considered to be biologically active.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.