Evidence map›Paper›PMID 31148503›Full record

SynthesisEnvironmental health perspectives2019

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.

Olena Gruzieva, Cheng-Jian Xu, Paul Yousefi, Caroline Relton, Simon Kebede Merid, Carrie V Breton, Lu Gao, Heather E Volk, Jason I Feinberg, Christine Ladd-Acosta and 44 more

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 7 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 7 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Early Life Exposure to Air Pollutants and Childhood Asthma.Current allergy and asthma reports · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Climate informed precision health.Frontiers in public health · 2026
    Article
  16. Multi-omics Data Integration.Advances in experimental medicine and biology · 2026
    Review
  17. Review
  18. Article
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

54 authors at 20 institutions in 11 countries.

Olena Gruzieva1 Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden.
Cheng-Jian Xu3 Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen , Netherlands.
Paul Yousefi6 MRC Integrative Epidemiology Unit, University of Bristol , Bristol, UK.
Caroline Relton6 MRC Integrative Epidemiology Unit, University of Bristol , Bristol, UK.
Simon Kebede Merid1 Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden.
Carrie V Breton8 Department of Preventive Medicine, University of Southern California Los Angeles , Los Angeles, California, USA.
Lu Gao8 Department of Preventive Medicine, University of Southern California Los Angeles , Los Angeles, California, USA.
Heather E Volk9 Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland, USA.
Jason I Feinberg9 Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland, USA.
Christine Ladd-Acosta11 Department of Epidemiology, School of Public Health, University of Michigan , Ann Arbor, Michigan, USA.
Kelly Bakulski11 Department of Epidemiology, School of Public Health, University of Michigan , Ann Arbor, Michigan, USA.
Charles Auffray12 European Institute for Systems Biology and Medicine (EISBM), CNRS-ENS-UCBL, Université de Lyon , Lyon, France.
Nathanaël Lemonnier12 European Institute for Systems Biology and Medicine (EISBM), CNRS-ENS-UCBL, Université de Lyon , Lyon, France.
Michelle Plusquin14 Centre for Environmental Sciences, Hasselt University , Diepenbeek, Belgium.
Akram Ghantous16 Epigenetics Group, International Agency for Research on Cancer, Lyon, France.
Zdenko Herceg16 Epigenetics Group, International Agency for Research on Cancer, Lyon, France.
Tim S Nawrot14 Centre for Environmental Sciences, Hasselt University , Diepenbeek, Belgium.
Costanza Pizzi18 Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte , Turin, Italy.
Lorenzo Richiardi18 Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte , Turin, Italy.
Franca Rusconi19 Unit of Epidemiology, Meyer Children's University Hospital , Florence, Italy.
Paolo Vineis15 MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , London, UK.
Manolis Kogevinas20 Barcelona Institute for Global Health (ISGlobal) , Barcelona, Spain.
Janine F Felix23 Generation R Study Group, Erasmus MC (Medical Centre) , University Medical Center Rotterdam , Rotterdam, Netherlands.
Liesbeth Duijts23 Generation R Study Group, Erasmus MC (Medical Centre) , University Medical Center Rotterdam , Rotterdam, Netherlands.
Herman T den Dekker23 Generation R Study Group, Erasmus MC (Medical Centre) , University Medical Center Rotterdam , Rotterdam, Netherlands.
Vincent W V Jaddoe23 Generation R Study Group, Erasmus MC (Medical Centre) , University Medical Center Rotterdam , Rotterdam, Netherlands.
José L Ruiz27 Center for Genomic Regulation (CRG) , Barcelona, Spain.
Mariona Bustamante20 Barcelona Institute for Global Health (ISGlobal) , Barcelona, Spain.
Josep Maria Antó20 Barcelona Institute for Global Health (ISGlobal) , Barcelona, Spain.
Jordi Sunyer20 Barcelona Institute for Global Health (ISGlobal) , Barcelona, Spain.
Martine Vrijheid20 Barcelona Institute for Global Health (ISGlobal) , Barcelona, Spain.
Kristine B Gutzkow30 Norwegian Institute of Public Health , Oslo, Norway.
Regina Grazuleviciene31 Department of Environmental Sciences, Vytauto Didziojo Universitetas , Kaunas, Lithuania.
Carles Hernandez-Ferrer20 Barcelona Institute for Global Health (ISGlobal) , Barcelona, Spain.
Isabella Annesi-Maesano33 Epidemiology of Allergic and Respiratory Diseases Department, IPLESP, Inserm and Sorbonne University Medical School Saint-Antoine , Paris, France.
Johanna Lepeule34 Université Grenoble Alpes, Inserm, National Institute of Health & Medical Research, CNRS, IAB , Grenoble, France.
Jean Bousquet35 Innovation Partnership on Active and Healthy Ageing Reference Site, MACVIA-France (Contre les Maladies Chroniques pour un Vieillissement Actif en France European) , Montpellier, France.
Anna Bergström1 Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden.
Inger Kull1 Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden.
Cilla Söderhäll39 Department of Women's and Children's Health, Karolinska Institutet , Stockholm, Sweden.
Juha Kere40 Department of Biosciences and Nutrition, Karolinska Institutet , Stockholm, Sweden.
Ulrike Gehring44 Institute for Risk Assessment Sciences, Utrecht University , Utrecht, Netherlands.
Bert Brunekreef44 Institute for Risk Assessment Sciences, Utrecht University , Utrecht, Netherlands.
Allan C Just46 Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai , New York, USA.
Rosalind J Wright47 Department of Pediatrics, Icahn School of Medicine at Mount Sinai , New York, USA.
Cheng Peng48 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts, USA.
Diane R Gold48 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts, USA.
Itai Kloog50 Department of Geography and Environmental Development, Ben-Gurion University of the Negev , Beer Sheva, Israel.
Dawn L DeMeo48 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts, USA.
Göran Pershagen1 Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden.
Gerard H Koppelman3 Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen , Netherlands.
Stephanie J London51 National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), U.S. Department of Health and Human Services , Research Triangle Park, North Carolina, USA.
Andrea A Baccarelli52 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health , New York, USA.
Erik Melén1 Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden.
Karolinska Institutet · SEErasmus MC · NLBrigham and Women's Hospital · USUtrecht University · NLBarcelona Institute for Global Health · ESBen-Gurion University of the Negev · ILCentre international de recherche sur le cancer · FRImperial College London · GBInserm · FRJohns Hopkins University · USMunicipal Institute for Medical Research · ESNational Institutes of Health · USPiedmont Reference Center for Epidemiology and Cancer Prevention · ITStockholm County Council · SEUniversité Claude Bernard Lyon 1 · FRUniversity Medical Center Groningen · NLUniversity of Bristol · GBUniversity of Michigan · USUniversity of Southern California · USBoston Children's Hospital · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
Racial inequalities in health throughout adulthood: The cumulative impact of neighborhood chemical and non-chemical stressors on epigenomic pathwaysR01MD013299 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKEN, MARGARET TAKAKO · 2018 to 2022
$3.7M
Folic Acid Prevention Pathways for ASD in High Risk FamiliesR01ES025574 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2015 to 2019
$3.1M
Prospective Evaluation of Air Pollution, Cognition, and Autism from Birth OnwardR01ES023780 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VOLK, HEATHER E · 2014 to 2017
$3.0M
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESR24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany D. Chambers Butcher, Rebecca Jean Schmidt · 2017 to 2026
$2.3M
Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_12013/2Medical Research Council MR/L01341X/1NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES023780NIEHS NIH HHS R01 ES025574NIEHS NIH HHS R24 ES028533NIMHD NIH HHS R01 MD013299World Health Organization 001
6 · The paper itself

Abstract

backgroundPrenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.

objectivesWe aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter [Formula: see text] ([Formula: see text]) or [Formula: see text] ([Formula: see text]) and DNA methylation in newborns and children.

methodsWe meta-analyzed associations between exposure to [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression.

resultsSix CpGs were significantly associated [false discovery rate (FDR) [Formula: see text]] with prenatal [Formula: see text] and 14 with [Formula: see text] exposure. Two of the [Formula: see text] CpGs mapped to FAM13A (cg00905156) and NOTCH4 (cg06849931) previously associated with lung function and asthma. Although these associations did not replicate in the smaller newborn sample, both CpGs were significant ([Formula: see text]) in 7- to 9-y-olds. For cg06849931, however, the direction of the association was inconsistent. Concurrent [Formula: see text] exposure was associated with a significantly higher NOTCH4 expression at age 16 y. We also identified several DMRs associated with either prenatal [Formula: see text] and or [Formula: see text] exposure, of which two [Formula: see text] DMRs, including H19 and MARCH11, replicated in newborns.

conclusionsSeveral differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes. https://doi.org/10.1289/EHP4522.

Indexed as

EpigenomeAdolescentAir PollutantsAir PollutionChildChild, PreschoolDNA MethylationFemaleFetal BloodHumansInfantInfant, NewbornMaleMaternal ExposureParticulate MatterPregnancyAir PollutantsParticulate Matter

Identifiers

PMID31148503
PMCPMC6792178
OpenAlexW2947990506

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.