Evidence map›Paper›PMID 31148372›Full record

ArticleJournal of the International AIDS Society2019

Validation of a self-report adherence measurement tool among a multinational cohort of children living with HIV in Kenya, South Africa and Thailand.

Rachel C Vreeman, Michael L Scanlon, Wanzhu Tu, James E Slaven, Carole I McAteer, Stephen J Kerr, Torsak Bunupuradah, Sararut Chanthaburanum, Karl-Günter Technau, Winstone M Nyandiko

Open access · goldAbstract readValidation Study
In one paragraph

Article in Journal of the International AIDS Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 5 countries.

Rachel C VreemanDepartment of Health Systems Design and Global Health, Arnhold Institute for Global Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5460-8204
Michael L ScanlonDepartment of Health Systems Design and Global Health, Arnhold Institute for Global Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wanzhu TuDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
James E SlavenDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Carole I McAteerAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Stephen J KerrHIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Torsak BunupuradahHIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Sararut ChanthaburanumHIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Karl-Günter TechnauDepartment of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, South Africa.
Winstone M NyandikoAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
HIV Netherlands Australia Thailand Research Collaboration · THIndiana University School of MedicineMount Sinai Health System · USAMPATH · KEChulalongkorn University · THMoi University · KEUniversity of the Witwatersrand · ZA

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI AGGREY SEMWENDERO SEMEERE, Kara Kay Wools-Kaloustian · 2006 to 2026
$57.7M
Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907NIAID NIH HHS U01 AI069911NIAID NIH HHS U01 AI069924
6 · The paper itself

Abstract

introductionThere are few data on adherence and low-cost measurement tools for children living with HIV. We collected prospective data on adherence to antiretroviral therapy (ART) among a multinational cohort of children to evaluate an adherence questionnaire.

methodsWe enrolled 319 children ages 0 to 16 years on ART in Kenya (n = 110), South Africa (n = 109) or Thailand (n = 100). Children were followed up for six months of adherence monitoring between March 2015 and August 2016 using Medication Event Monitoring Systems (MEMS

resultsMean child age was 11 years and 54% were female. Children from Thailand (median age 14 years) were significantly older compared to Kenya (10 years) and South Africa (10 years). Prevalence of viral suppression was 97% in Thailand, 81% in South Africa and 69% in Kenya, while the prevalence of MEMS

conclusionsWe found suboptimal adherence to ART was common by multiple measures in this multi-country cohort of children. The short-form questionnaire demonstrated reasonable validity to screen for non-adherence in these diverse settings.

Indexed as

Drug MonitoringAdolescentAdultAnti-HIV AgentsCaregiversChildChild, PreschoolFemaleHIV InfectionsHumansInfantInfant, NewbornKenyaMaleProspective StudiesSelf ReportAnti-HIV AgentsadherencechildrenHIV/AIDSKenyaSouth AfricaThailand

Identifiers

PMID31148372
PMCPMC6543456
OpenAlexW2948026419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.