ArticleThe Plant journal : for cell and molecular biology2019
The Arabidopsis non-host defence-associated coumarin scopoletin protects soybean from Asian soybean rust.
Article in The Plant journal : for cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 69 citations in OpenAlex.
- AtMYB72 as a Biotechnological Tool to Overcome Phenylpropanoid Substrate Limitation and Enhance Coumarin Biosynthesis in Plants.Plant biotechnology journal · 2026Article
- Metabolomic Insights into MYMV Resistance: Biochemical Complexity in Mung Bean Cultivars.Pathogens (Basel, Switzerland) · 2025Article
- Negative Immune Regulator CAD7 Functions as a Small-Molecule Aldehyde Reductase and Increases Histamine Accumulation in Arabidopsis.Molecular plant pathology · 2025Article
- Phenolic Compounds Accumulation and Cell Death Degree Induced by Fusaric Acid in Agroforestry Hosts Plants ofJournal of fungi (Basel, Switzerland) · 2025Article
- MS-UNet: A Hybrid Network with a Multi-Scale Vision Transformer and Attention Learning Confusion Regions for Soybean Rust Fungus.Sensors (Basel, Switzerland) · 2025Article
- Origin and de novo domestication of sweet orange.Nature genetics · 2025Article
- The biosynthetic pathway of coumarin and its genetic regulation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Transcriptome responses of Arabidopsis to necrotrophic fungus Alternaria brassicae reveal pathways and candidate genes associated with resistance.Plant molecular biology · 2024Article
- Rapidly mining candidate cotton drought resistance genes based on key indicators of drought resistance.BMC plant biology · 2024Article
- Engineered coumarin accumulation reduces mycotoxin-induced oxidative stress and disease susceptibility.Plant biotechnology journal · 2023Article
- Identification of a Novel Coumarins Biosynthetic Pathway in the Endophytic Fungus Fusarium oxysporum GU-7 with Antioxidant Activity.Applied and environmental microbiology · 2023Article
- Metabolic pathway genes for editing to enhance multiple disease resistance in plants.Journal of plant research · 2022Article
- Physiological adjustment of pomegranate pericarp responding to sunburn and its underlying molecular mechanisms.BMC plant biology · 2022Article
- Progress in soybean functional genomics over the past decade.Plant biotechnology journal · 2022Review
- Physiological and transcriptome profiling revealed defense networks duringFrontiers in plant science · 2022Article
- Retrieving theFrontiers in microbiology · 2022Article
- Disclosure of salicylic acid and jasmonic acid-responsive genes provides a molecular tool for deciphering stress responses in soybean.Scientific reports · 2021Article
- Characterisation, pathogenicity and hydrolytic enzyme profiling of selected Fusarium species and their inhibition by novel coumarins.Archives of microbiology · 2021Article
- Untargeted Metabolomics Analysis by UHPLC-MS/MS of Soybean Plant in a Compatible Response toMetabolites · 2021Article
- Transcriptome Signatures inMicroorganisms · 2021Article
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6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The fungus Phakopsora pachyrhizi (Pp) causes Asian soybean rust (SBR) disease which provokes tremendous losses in global soybean production. Pp is mainly controlled with synthetic fungicides to which the fungus swiftly develops fungicide resistance. To substitute or complement synthetic fungicides in Asian soybean rust control, we aimed to identify antifungal metabolites in Arabidopsis which is not a host for Pp. Comparative transcriptional and metabolic profiling of the Pp-inoculated Arabidopsis non-host and the soybean host revealed induction of phenylpropanoid metabolism-associated genes in both species but activation of scopoletin biosynthesis only in the resistant non-host. Scopoletin is a coumarin and an antioxidant. In vitro experiments disclosed fungistatic activity of scopoletin against Pp, associated with reduced accumulation of reactive oxygen species (ROS) in fungal pre-infection structures. Non-antioxidant and antioxidant molecules including coumarins with a similar structure to scopoletin were inactive or much less effective at inhibiting fungal accumulation of ROS and germination of Pp spores. When sprayed onto Arabidopsis leaves, scopoletin also suppressed the formation of Pp pre-infection structures and penetration of the plant. However, scopoletin neither directly activated defence nor did it prime Arabidopsis for enhanced defence, therefore emphasizing fungistatic activity as the exclusive mode of action of scopoletin against Pp. Because scopletin also protected soybean from Pp infection, the coumarin may serve as a natural fungicide or as a lead for the development of near-to-nature fungicides against Asian soybean rust.
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