ArticleHeadache2019
Chronobiology and Sleep in Cluster Headache.
Article in Headache, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Cluster headache suicidality: a systematic review with a meta-analysis.The journal of headache and pain · 2025Pooled it
- Circadian pain patterns in human pain conditions - A systematic review.Pain practice : the official journal of World Institute of Pain · 2023Pooled it
- Examining Laterality in Masticatory Myofascial Pain.Journal of oral rehabilitation · 2026Article
- Sleep Domain Predictors of Headache-Related Disability in Episodic Migraine and Cluster Headache: A Prospective Observational Cohort Study.Journal of clinical medicine · 2026Article
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- Circadian attributes of neurological and psychiatric disorders as basis for their medication chronotherapy.Advanced drug delivery reviews · 2025Review
- Reviewing the complex relationship between circadian rhythms and cluster headache.Cephalalgia : an international journal of headache · 2025Review
- Circadian Rhythms and Pain: A Narrative Review on Clock Genes and Circadian-Based Interventions.Journal of pain research · 2025Review
- Pre-cluster symptoms in a Taiwanese cohort of cluster headache: symptom profiles and clinical predictions.The journal of headache and pain · 2024Article
- Cluster headache: understandings of current knowledge and directions for whole process management.Frontiers in neurology · 2024Review
- Sleep and Chronobiology as a Key to Understand Cluster Headache.Neurology international · 2023Review
- Sphenopalatine ganglion volumetry in episodic cluster headache: from symptom laterality to cranial autonomic symptoms.The journal of headache and pain · 2023Article
- Single-nucleus transcriptome analysis reveals transcriptional profiles of circadian clock and pain related genes in human and mouse trigeminal ganglion.Frontiers in neuroscience · 2023Article
- Current Understanding of the Chronobiology of Cluster Headache and the Role of Sleep in Its Management.Nature and science of sleep · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCluster headache attacks follow a striking circadian rhythm with an intriguing influence of sleep. We aim to investigate differences in sleep quality, chronotype, and the ability to alter individual sleep rhythms in episodic and chronic cluster headache patients vs controls.
methodsCluster headache patients and non-headache controls from the Dutch Leiden University Cluster headache neuro-Analysis program aged 18 and above completed web-based questionnaires in a cross-sectional study.
resultsA total of 478 episodic, 147 chronic cluster headache patients and 367 controls participated. Chronic cluster headache patients had more often early chronotypes than controls, as measured by mid-sleep phase (P = .021 adjusted B -15.85 minutes CI -29.30; -2.40). Compared to controls, chronic cluster headache participants were less able to alter their sleep rhythms (P < .001 adjusted B -1.65 CI -2.55; 0.74), while episodic cluster headache participants reported more difficulty in coping with reduced sleep (P = .025 adjusted B 0.75 CI 0.09; 1.40). Sleep quality was reduced in both types of cluster headache compared to controls ("poor sleepers": 71.4% (105/147) in chronic and 48.3% (235/367) in episodic cluster headache vs 25.6% (94/367) in controls; both P < .001; episodic adjusted B -1.71 CI 0.10; 0.32; chronic adjusted B -0.93 CI 0.24; 0.65).
conclusionSleep quality is decreased in both episodic and chronic cluster headache, most likely caused by cluster headache attacks that strike during the night. Episodic cluster headache patients report more difficulty in coping with reduced sleep, while chronic patients are less able to alter their sleep rhythm. Although not directly proven, cluster headache patients will likely benefit from a structured, regular daily schedule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.