Evidence map›Paper›PMID 31147888›Full record

ReviewJournal of muscle research and cell motility2019

The giant titin: how to evaluate its role in cardiomyopathies.

Amar Azad, Giulia Poloni, Naeramit Sontayananon, He Jiang, Katja Gehmlich

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of muscle research and cell motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. [Recent studies on dilated cardiomyopathy caused byZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
  3. Article
  4. Discerning the Ambiguous Role of MissenseJournal of personalized medicine · 2022
    Article
  5. Article
  6. The Role of Z-disc Proteins in Myopathy and Cardiomyopathy.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Mammalian muscle fibers may be simple as well as slow.The Journal of general physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amar AzadDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, OX3 9DU, UK.
Giulia PoloniDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, OX3 9DU, UK.
Naeramit SontayananonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, OX3 9DU, UK.
He JiangDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, OX3 9DU, UK.
Katja GehmlichDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, OX3 9DU, UK. k.gehmlich@bham.ac.uk.ORCID 0000-0003-4019-1844
British Heart Foundation · GB

Funding

British Heart Foundation FS/12/40/29712British Heart Foundation PG/15/113/31944Wellcome Trust 201543/B/16/ZWellcome Trust 201543/Z/16/Z
6 · The paper itself

Abstract

Titin, the largest protein known, has attracted a lot of interest in the cardiovascular field in recent years, since the discovery that truncating variants in titin are commonly found in patients with dilated cardiomyopathy. This review will discuss the contribution of variants in titin to inherited cardiac conditions (cardiomyopathies) and how model systems, such as animals and cellular systems, can help to provide insights into underlying disease mechanisms. It will also give an outlook onto exciting technological developments, such as in the field of CRISPR, which may facilitate future research on titin variants and their contributions to cardiomyopathies.

Indexed as

Cardiomyopathy, DilatedConnectinHeart Defects, CongenitalAnimalsHumansConnectinTTN protein, humanAnimal modelsCardiomyopathyCRISPR/Cas9Genome-engineeringInduced pluripotent stem cell derived cardiomyocytesTitin

Identifiers

PMID31147888
PMCPMC6726704
OpenAlexW2947279776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.