ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Brain volume is related to neurological impairment and to copper overload in Wilson's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Brain microstructural abnormalities in patients with Wilson's disease: A systematic review of diffusion tenor imaging studies.Brain imaging and behavior · 2022Pooled it
- Phenotype-specific white matter microstructural alterations and their clinical correlates in Wilson disease.Scientific reports · 2026Article
- Association of dietary copper intake with Alzheimer's disease, brain structure and cognitive function.The journal of nutrition, health & aging · 2026Article
- Atrophy related neuroimaging biomarkers for neurological and cognitive function in Wilson disease.Neurological research and practice · 2025Article
- Copper homeostasis and cuproptosis: implications for neurodegenerative diseases.Frontiers in aging neuroscience · 2025Review
- Brain Magnetic Resonance Imaging in Wilson's Disease-Significance and Practical Aspects-A Narrative Review.Brain sciences · 2024Review
- The Role of Glia in Wilson's Disease: Clinical, Neuroimaging, Neuropathological and Molecular Perspectives.International journal of molecular sciences · 2024Review
- Mapping brain volume change across time in primary-progressive multiple sclerosis.Neuroradiology · 2024Article
- The physiological and pathophysiological roles of copper in the nervous system.The European journal of neuroscience · 2024Review
- Association of Motor Function With Cognitive Trajectories and Structural Brain Differences: A Community-Based Cohort Study.Neurology · 2023Article
- Optical coherence tomography in patients with Wilson's disease.Brain and behavior · 2023Article
- Blood Based Biomarkers of Central Nervous System Involvement in Wilson's Disease.Diagnostics (Basel, Switzerland) · 2023Review
- A weighted cranial diffusion-weighted imaging scale for Wilson's disease.Frontiers in neuroscience · 2023Article
- A study of linear measurement and clinical correlation of brain atrophy in Wilson's disease.Frontiers in human neuroscience · 2023Article
- A Novel Cuproptosis-Related Signature Identified DLAT as a Prognostic Biomarker for Hepatocellular Carcinoma Patients.World journal of oncology · 2022Article
- Neuroimaging correlates of brain injury in Wilson's disease: a multimodal, whole-brain MRI study.Brain : a journal of neurology · 2022Article
- Increased Magnetic Susceptibility in the Deep Gray Matter Nuclei of Wilson's Disease: Have We Been Ignoring Atrophy?Frontiers in neuroscience · 2022Article
- Disrupted topological organization of the motor execution network in Wilson's disease.Frontiers in neurology · 2022Article
- Blink reflex in newly diagnosed and treated patients with Wilson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2021Observational
- The effects of copper sulfate on the structure and function of the rat cerebellum: A stereological and behavioral study.IBRO neuroscience reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo determine whether brain volume was associated with functional and neurological impairments and with copper overload markers in patients with Wilson's disease.
methodsIn 48 treatment-naïve patients, we assessed functional and neurological impairments with the Unified Wilson's Disease Rating Scale, measured normalized brain volumes based on magnetic resonance images, and assessed concentration of non-ceruloplasmin-bound copper. We correlated brain volume measures with functional and neurological impairment scores and copper overload indices.
resultsFunctional and neurological impairments correlated with all brain volume measures, including the total brain volume and the volumes of white matter and gray matter (both peripheral gray matter and deep brain nuclei). Higher non-ceruloplasmin-bound copper concentrations were associated with greater functional and neurological impairments and lower brain volumes.
conclusionsOur findings provided the first in vivo evidence that the severity of brain atrophy is a correlate of functional and neurological impairments in patients with Wilson's disease and that brain volume could serve as a marker of neurodegeneration induced by copper.
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