Evidence map›Paper›PMID 31147793›Full record

ArticleMikrochimica acta2019

An electrochemical aptasensing platform for carbohydrate antigen 125 based on the use of flower-like gold nanostructures and target-triggered strand displacement amplification.

Jishun Chen, Wanbao Hu, Jian Wei, Fei Yu, Lun Wu, Ceming Wang, Wei Wang, Shenyuan Zuo, Bing Shang, Qinhua Chen

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Aptamer Nanomaterials for Ovarian Cancer Target Theranostics.Frontiers in bioengineering and biotechnology · 2022
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jishun ChenAffiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, China.
Wanbao HuSinopharm DongfengHuaguo Hospital, Shiyan, 442008, Hubei, China.
Jian WeiAffiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, China.
Fei YuAffiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, China.
Lun WuAffiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, China.
Ceming WangAffiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, China.
Wei WangSinopharm DongfengHuaguo Hospital, Shiyan, 442008, Hubei, China.
Shenyuan ZuoSinopharm DongfengHuaguo Hospital, Shiyan, 442008, Hubei, China.
Bing ShangAffiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, China. bingshang1126@163.com.
Qinhua ChenAffiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, China. cqh77@163.com.

Funding

Free Exploration Project of Hubei University of Medicine FDFR201804Hubei Provincial Technology Innovation Project 2017ACA176Key Discipline Project of Hubei University of Medicine and the Foundation of Health Commission of Hubei Province WJ2019M054National Natural Science Foundation of China 81872509Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research WDCM2018004Research Project of Traditional Chinese Medicine of the Foundation of Health Commission of Hubei Province ZY2019M034Science and Technology Key Program of Shiyan 18Y101Science and Technology Key Program of Shiyan 18Y102Science and Technology Key Program of Shiyan 18Y104
6 · The paper itself

Abstract

An electrochemical aptasensing method is described for the determination of the biomarker CA125. It combines aptamer recognition and target-triggered strand displacement amplification. Flower like gold nanostructures were electrodeposited on a screen-printed carbon electrode to increase the sensor surface, to assemble more toehold-containing hairpin probe 1 (Hp1), and to improve the accessibility for DNA strands. Under the optimal conditions, this assay has a linear response in the 0.05 to 50 ng•mL

Indexed as

Aptamers, NucleotideBiosensing TechniquesCA-125 AntigenCarbonDNADNA ProbesElectrochemical TechniquesElectrodesGoldHumansLimit of DetectionMembrane ProteinsMetal NanoparticlesNucleic Acid Amplification TechniquesNucleic Acid HybridizationSalivaAptamers, NucleotideCA-125 AntigenCarbonDNADNA ProbesGoldMembrane ProteinsMUC16 protein, humanAptamerAptasensorCancer biomarkerOvarian cancerToehold

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.