Evidence map›Paper›PMID 31147744›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2019

Minimizing transfusion in sagittal craniosynostosis surgery: the Children's Hospital of Minnesota Protocol.

Paul J Escher, Albert Tu, Susan Kearney, Matthew Wheelwright, Joseph Petronio, Meysam Kebriaei, Sivakumar Chinnadurai, Robert J Tibesar

Abstract read
PubMed Publisher
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Efficacy and safety of sagittal synostosis surgery in older (> 12 months) patients: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Paul J EscherUniversity of Minnesota Medical School, Minneapolis, MN, USA.
Albert TuChildren's Minnesota Department of Neurosurgery, Minneapolis, MN, USA.
Susan KearneyChildren's Minnesota Center for Bleeding and Clotting Disorders, Minneapolis, MN, USA.
Matthew WheelwrightUniversity of Minnesota Medical School, Minneapolis, MN, USA.
Joseph PetronioChildren's Minnesota Department of Neurosurgery, Minneapolis, MN, USA.
Meysam KebriaeiChildren's Minnesota Department of Neurosurgery, Minneapolis, MN, USA.
Sivakumar ChinnaduraiChildren's Minnesota ENT and Craniofacial Surgery, Minneapolis, MN, USA.
Robert J TibesarChildren's Minnesota ENT and Craniofacial Surgery, Minneapolis, MN, USA. Robert.tibesar@childrensmn.org.
Children's Minnesota · USUniversity of Minnesota Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the success of a protocol using preoperative erythropoietin (EPO) and iron with perioperative tranexamic acid (TXA) in reducing blood transfusion in sagittal craniosynostosis surgery.

methodsA retrospective chart review of all sagittal craniosynostosis patients undergoing open repair at our institution since 2010 was conducted. A novel protocol of preoperative EPO with iron and perioperative TXA, along with a shift away from automatic transfusion, was initiated in 2014. Perioperative hemoglobin levels, length of stay, and transfusion rates were compared between the historical control and the study group receiving the protocol.

resultsA total of 36 patients met inclusion criteria. Twenty-eight patients were male and 8 were female. Twenty-two patients were in the control group receiving neither TXA nor EPO and automatically received a transfusion, while 14 were in the study group and received the full protocol. There were no significant demographic differences between groups. Within the control group, 100% of patients were transfused compared with 14.3% of the study group (p < 0.0001). The study group also had a shorter postoperative length of stay in the hospital (mean, 3.4 days; range, 3-6) than the control (mean, 4 days; range, 2-5.5, p = 0.038). The study group had a higher preoperative hemoglobin than the control (13.6 vs. 11.8 g/dL, p = 0.0001).

conclusionOur protocol of preoperative EPO and iron with perioperative TXA increased the preoperative hemoglobin and was associated with a low transfusion rate without negatively impacting postoperative course.

Indexed as

Blood TransfusionAntifibrinolytic AgentsBlood Loss, SurgicalChildClinical ProtocolsCraniosynostosesErythropoietinFemaleHemoglobinsHospitals, PediatricHumansIronMaleMinnesotaPlastic Surgery ProceduresRetrospective StudiesAntifibrinolytic AgentsEPO protein, humanErythropoietinHemoglobinsIronTranexamic AcidErythropoietinSagittal craniosynostosisTranexamic acid

Identifiers

PMID31147744
OpenAlexW2947911722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.