Evidence map›Paper›PMID 31147718›Full record

ArticleNucleic acids research2019

RNAmod: an integrated system for the annotation of mRNA modifications.

Qi Liu, Richard I Gregory

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 181 citations in OpenAlex.

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  15. NNMT-mediated NOncogene · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. The Role of N6-Methyladenosine in Mitochondrial Dysfunction and Pathology.International journal of molecular sciences · 2025
    Review
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qi LiuStem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
Richard I GregoryStem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
Boston Children's Hospital · US

Funding

Regulation of microRNA Biogenesis in Stem CellsR01GM086386 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI GREGORY, RICHARD I. · 2009 to 2018
$3.1M
Regulation of the LIN28/let-7 pathway in cancerR01CA211328 · NCI · BOSTON CHILDREN'S HOSPITAL · PI GREGORY, RICHARD I. · 2017 to 2019
$1.2M
NCI NIH HHS R01 CA211328NIGMS NIH HHS R01 GM086386
6 · The paper itself

Abstract

Dynamic and reversible RNA modifications such as N6-methyladenosine (m6A) can play important roles in regulating messenger RNA (mRNA) splicing, export, stability and translation. Defective mRNA modification through altered expression of the methyltransferase and/or demethylases results in developmental defects and cancer progression. Identifying modified mRNAs, annotating the distribution of modification sites across the mRNA, as well as characterizing and comparing other modification features are essential for studying the function and elucidating the mechanism of mRNA modifications. Several methods including methylated RNA immunoprecipitation and sequencing (MeRIP-seq) are available for the detection of mRNA modifications. However, a convenient and comprehensive tool to annotate diverse kinds of mRNA modifications in different species is lacking. Here, we developed RNAmod (https://bioinformatics.sc.cn/RNAmod), an interactive, one-stop, web-based platform for the automated analysis, annotation, and visualization of mRNA modifications in 21 species. RNAmod provides intuitive interfaces to show outputs including the distribution of RNA modifications, modification coverage for different gene features, functional annotation of modified mRNAs, and comparisons between different groups or specific gene sets. Furthermore, sites of known RNA modification, as well as binding site data for hundreds of RNA-binding proteins (RBPs) are integrated in RNAmod to help users compare their modification data with known modifications and to explore the relationship with the binding sites of known RBPs. RNAmod is freely available and meets the emerging need for a convenient and comprehensive analysis tool for the fast-developing RNA modification field.

Indexed as

Molecular Sequence AnnotationRNA Processing, Post-TranscriptionalSoftwareAnimalsBinding SitesHumansMiceRatsRNA-Binding ProteinsRNA, MessengerSystems IntegrationRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID31147718
PMCPMC6602476
OpenAlexW2947993870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.