SynthesisAdvances in nutrition (Bethesda, Md.)2019
Oropharyngeal Colostrum for Preterm Infants: A Systematic Review and Meta-Analysis.
Synthesis in Advances in nutrition (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis.Revista de saude publica · 2021Pooled it
- Nutritional interventions to reduce rates of infection, necrotizing enterocolitis and mortality in very preterm infants.Pediatric research · 2020Pooled it
- Investigating the effect of oropharyngeal colostrum in the prevention of late-onset sepsis in preterm infants: a randomized controlled trial.Scientific reports · 2025Trial
- Oral Application of Colostrum and Mother's Own Milk in Preterm Infants-A Randomized, Controlled Trial.Indian journal of pediatrics · 2022Trial
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational age ≤ 32 weeks: a pilot single-center randomized controlled trial.International breastfeeding journal · 2021Trial
- Oropharyngeal Colostrum Positively Modulates the Inflammatory Response in Preterm Neonates.Nutrients · 2020Trial
- Oropharyngeal colostrum administration in neonates with gastroschisis: a randomized clinical trial.Critical care scienceTrial
- Enhancing early mother's own milk (MOM) use in NICU preterm infants with colostrum oral immune therapy (COIT): evidence summary.Translational pediatrics · 2025Article
- Short-term outcomes of oropharyngeal administration of colostrum in preterm neonates: a double-blind placebocontrolled randomized trial.Clinical and experimental pediatrics · 2025Article
- Interventions to improve comfort and physiological parameters in premature infants: a meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Article
- Effects of non-pharmacological interventions on sleep in premature infants: meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Oropharyngeal Colostrum Administration in Premature Infants: Impact on Immune Status and Incidence of Common Morbidities.International journal of preventive medicine · 2024Article
- Colostrum and Preterm Babies: A Systematic Review.Cureus · 2023Review
- Effectiveness of early enteral feeding on health outcomes in preterm infants: an overview of systematic reviews.European journal of clinical nutrition · 2023Review
- Chlorine Solutions for a Safe Method of Decontamination of Breast Pump Milk Collection Kits Before and After the Coronavirus Disease 2019 Pandemic.Frontiers in nutrition · 2021Article
- Current Resources for Evidence-Based Practice, November 2020.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Administration of oropharyngeal colostrum (OPC) is safe, feasible, and potentially beneficial in preterm infants. We aimed to assess the effects of OPC in preterm infants. A systematic review of randomized controlled trials (RCTs) and non-RCTs of OPC administration in preterm infants was conducted. We searched MEDLINE via PubMed and Ovid, EMBASE, the Cochrane Central Register of Controlled Trials, Emcare databases, abstracts of Pediatric Academic Societies meetings, and gray literature in April 2018. Six RCTs (n = 269) and 4 non-RCTs (n = 737) were included. One RCT (n = 40) focused on enteral bovine colostrum and hence was excluded from our review. Five of the 6 RCTs had unclear risk of bias in many domains of assessment. Meta-analysis (random effects model) of RCT data showed no significant difference in ≥stage 2 necrotizing enterocolitis (RR: 0.83; 95% CI: 0.39, 1.75; P = 0.62), late-onset sepsis (RR: 0.78; 95% CI: 0.50, 1.22; P = 0.28), all-cause mortality (RR: 0.74; 95% CI: 0.27, 2.06; P = 0.56); duration of hospital stay (mean difference [MD]: -1.65 d; 95% CI: -10.09, 6.80; P = 0.70), and time to full feeds (MD: -2.86 d; 95% CI: -6.49, 0.77; P = 0.12). Meta-analysis of data from non-RCTs also showed no benefit for any of these outcomes. OPC increased secretory IgA and lactoferrin concentrations (4 RCTs), and had only a transient effect on the oral microbiome (1 RCT). There were no adverse effects (e.g., aspiration) of OPC. The overall quality of evidence (Grades of Recommendation, Assessment, Development, and Evaluation analysis) was very low. Adequately powered RCTs are needed to confirm the nutritional and immunomodulatory benefits of OPC in preterm infants.
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