ArticleScientific reports2019
Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Brain Natriuretic Peptide for Predicting Contrast-Induced Acute Kidney Injury in Patients with Acute Coronary Syndrome Undergoing Coronary Angiography: A Systematic Review and Meta-Analysis.Journal of interventional cardiology · 2020Pooled it
- Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article.Eye (London, England) · 2025Review
- OCTA evaluates changes in retinal microvasculature in renal hypertension patients.Scientific reports · 2024Article
- Review
- Predictive value of combining urinary N-acetyl-β-D-glucosaminidase and serum homocysteine for contrast-induced nephropathy in patients after percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2024Article
- Correlation Between Coronary and Retinal Microangiopathy in Patients With STEMI.Translational vision science & technology · 2023Article
- Retinal Microvascular Changes in Familial Hypercholesterolemia: Analysis with Swept-Source Optical Coherence Tomography Angiography.Journal of personalized medicine · 2022Article
- Impact of Arterial Hypertension on the Eye: A Review of the Pathogenesis, Diagnostic Methods, and Treatment of Hypertensive Retinopathy.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature.Circulation · 2022Article
- Identification of Subclinical Microvascular Biomarkers in Coronary Heart Disease in Retinal Imaging.Translational vision science & technology · 2021Article
- Prediction of Cardiovascular Parameters With Supervised Machine Learning From Singapore "I" Vessel Assessment and OCT-Angiography: A Pilot Study.Translational vision science & technology · 2021Article
- Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients.Scientific reports · 2020Article
- The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons.Kidney international · 2020Review
- Retinal Microvasculature Causally Affects the Brain Cortical Structure: A Mendelian Randomization Study.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iodinated contrast agent (ICA)-induced acute kidney injury (AKI) following acute coronary syndrome (ACS) is a frequent complication, which may lead to chronic kidney disease and increased mortality. Optical coherence tomography angiography (OCT-A) of the retina is new tool delivering a rapid and noninvasive assessment of systemic microvascularization, which is potentially involved in the occurrence of ICA-induced AKI. Between October 2016 and March 2017, 452 ACS patients were admitted to our cardiac intensive care unit. OCT-A was performed within 48 h after the ICA injection. Patients with a history of retinal disease were excluded. The patients included were divided into two groups depending on whether or not AKI occurred after injection of ICA, according to KDIGO criteria. Of the 216 patients included, 21 (10%) presented AKI. AKI was significantly associated with age, Mehran score, GRACE score, and NT-proBNP. AKI patients had significantly lower retinal vascular density (RVD)) and had more frequent low RVD (81% vs 45%, P = 0.002). Adding low RVD to the Mehran score and the NT-proBNP, or to the GRACE score and the NT-proBNP, significantly improved their predictive values, suggesting that systemic microvascular involvement remains incompletely addressed by either standard risk scores or factors known to be associated with ICA-induced AKI.
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