ArticleNature communications2019
Sensory perception of dead conspecifics induces aversive cues and modulates lifespan through serotonin in Drosophila.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ageing effects of social environments in 'non-social' insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Pooled it
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
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- High-saturated-fat diet drives female-biased neurodegeneration inFrontiers in aging neuroscience · 2026Article
- Distribution Analysis of the Lifespan Trait in Drosophila.International journal of molecular sciences · 2025Article
- The exploration of consciousness in insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Modulation of C. elegans behavior, fitness, and lifespan by AWB/ASH-dependent death perception.Current biology : CB · 2025Article
- Perception and Longevity Control in Invertebrate Model Organisms-A Mini-Review of Recent Advances.Biomolecules · 2025Review
- Review
- Constitutive and Conditional Epitope Tagging of Endogenous G-Protein-Coupled Receptors inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Life-History Trade-Offs in Drosophila: Flies Select a Diet to Maximize Reproduction at the Expense of Lifespan.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Article
- Ring neurons in the Drosophila central complex act as a rheostat for sensory modulation of aging.PLoS biology · 2023Article
- Association between the loudness dependence of auditory evoked potentials and age in patients with schizophrenia and depression.The Journal of international medical research · 2022Article
- The deleterious effects of old social partners on Drosophila lifespan and stress resistance.npj aging · 2022Article
- Phenotyping ofBiomolecules · 2022Review
- The serotonin receptor 5-HT2A modulates lifespan and protein feeding inFrontiers in aging · 2022Article
- Article
- Social perception of young adults prolongs the lifespan of aged Drosophila.NPJ aging and mechanisms of disease · 2021Article
- Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila.Disease models & mechanisms · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Sensory perception modulates health and aging across taxa. Understanding the nature of relevant cues and the mechanisms underlying their action may lead to novel interventions that improve the length and quality of life. We found that in the vinegar fly, Drosophila melanogaster, exposure to dead conspecifics in the environment induced cues that were aversive to other flies, modulated physiology, and impaired longevity. The effects of exposure to dead conspecifics on aversiveness and lifespan required visual and olfactory function in the exposed flies. Furthermore, the sight of dead flies was sufficient to produce aversive cues and to induce changes in the head metabolome. Genetic and pharmacologic attenuation of serotonergic signaling eliminated the effects of exposure on aversiveness and lifespan. Our results indicate that Drosophila have an ability to perceive dead conspecifics in their environment and suggest conserved mechanistic links between neural state, health, and aging; the roots of which might be unearthed using invertebrate model systems.
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Registered trials
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