Evidence map›Paper›PMID 31147445›Full record

ArticleThe Journal of biological chemistry2019

Phosphatidylinositol 4,5-bisphosphate drives Ca

Mazdak M Bradberry, Huan Bao, Xiaochu Lou, Edwin R Chapman

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. PI(4,5)PBiochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Dynamic Formation of the Protein-Lipid Pre-fusion Complex.bioRxiv : the preprint server for biology · 2024
    Article
  11. Phospholipids Differentially Regulate CaACS chemical biology · 2024
    Article
  12. Article
  13. Article
  14. Calcium Sensors of Neurotransmitter Release.Advances in neurobiology · 2023
    Article
  15. Review
  16. Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  17. Article
  18. Review
  19. Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mazdak M BradberryHoward Hughes Medical Institute and the Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706 and; Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705.
Huan BaoHoward Hughes Medical Institute and the Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706 and.
Xiaochu LouHoward Hughes Medical Institute and the Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706 and.
Edwin R ChapmanHoward Hughes Medical Institute and the Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706 and. Electronic address: chapman@wisc.edu.
Howard Hughes Medical Institute · US

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Synaptotagmin C2B Domain as a Ca2+ Sensing ModuleR01MH061876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2002 to 2026
$7.7M
Structure and dynamics of exocytotic fusion poresR35NS097362 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPMAN, EDWIN R · 2017 to 2024
$4.6M
Mechanisms of calcium-dependent neurotransmitter release in health and diseaseF30MH116580 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI BRADBERRY, MAZDAK · 2018 to 2020
$120k
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM008692NIMH NIH HHS F30 MH116580NIMH NIH HHS R01 MH061876NINDS NIH HHS R35 NS097362
6 · The paper itself

Abstract

Exocytosis mediates the release of neurotransmitters and hormones from neurons and neuroendocrine cells. Tandem C2 domain proteins in the synaptotagmin (syt) and double C2 domain (Doc2) families regulate exocytotic membrane fusion via direct interactions with Ca

Indexed as

AnimalsC2 DomainsCalciumCalcium-Binding ProteinsCell MembraneExocytosisMembrane FusionMembrane LipidsNerve Tissue ProteinsNeuronsNeurotransmitter AgentsPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsProtein BindingSynapsesSynaptic TransmissionCalciumCalcium-Binding ProteinsDOC2B protein, humanMembrane LipidsNerve Tissue ProteinsNeurotransmitter AgentsPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsSynaptotagmin Icalcium-binding proteincalcium sensorexocytosismembrane biophysicsmembrane proteinphosphatidylinositol (4,5)-bisphosphate (PIP2)poly-anionic phospholipidsynapsesynaptotagmintandem C2 domain protein

Identifiers

PMID31147445
PMCPMC6635456
OpenAlexW2947865249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.