ArticleThe Journal of biological chemistry2019
Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice.
Open access · hybridAbstract read
In one paragraph
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- A Seven Amino Acid Long Region in the Cardiac CaCells · 2026Article
- Local calcium dynamics and signalling in cardiomyocytes.Nature reviews. Cardiology · 2026Review
- Multiscale stochastic modeling for calcium dynamics in cardiac electrophysiology: assessing whole-cell model reliability under phosphorylation and LCC downregulation.Frontiers in network physiology · 2026Article
- RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure.Cardiovascular research · 2025Article
- Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review.Circulation · 2025Review
- Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.NPJ Regenerative medicine · 2025Article
- Interleukin 11 therapy causes acute left ventricular dysfunction.Cardiovascular research · 2024Article
- Rad-mediated inhibition of CaThe Journal of physiology · 2024Article
- Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac CaBMC biology · 2024Article
- A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings.Science advances · 2024Article
- Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes.The Journal of general physiology · 2024Article
- The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation.The Journal of general physiology · 2024Article
- Circadian Regulation of Cardiac Arrhythmias and Electrophysiology.Circulation research · 2024Review
- A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.The Journal of clinical investigation · 2024Article
- Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.Research square · 2023Article
- Diversity of cells and signals in the cardiovascular system.The Journal of physiology · 2023Article
- Sympathetic Nervous System Regulation of Cardiac Calcium Channels.Handbook of experimental pharmacology · 2023Article
- Impairment of β-adrenergic regulation and exacerbation of pressure-induced heart failure in mice with mutations in phosphoregulatory sites in the cardiac CaFrontiers in physiology · 2023Article
- Rad regulation of CaNature cardiovascular research · 2022Article
- Convergent regulation of CaProceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 3 countries.
Brooke M AhernDepartment of Physiology.
Bryana M LevitanDepartment of Physiology,; Gill Heart and Vascular Institute, and.
Sudhakar VeerankiDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536 and.
Mihir ShahDepartment of Physiology.
Nemat AliDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536 and.
Andrea SebastianDepartment of Physiology.
Wen SuDepartment of Physiology.
Ming C GongDepartment of Physiology.
Jiayang LiDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Julian E StelzerDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Douglas A AndresDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536 and. Electronic address: dandres@uky.edu.
Jonathan SatinDepartment of Physiology,. Electronic address: Jsatin1@uky.edu.
Czech Academy of Sciences, Institute of Physiology · CZCase Western Reserve University · USUniversity of Kentucky · USBon Secours Heart & Vascular Institute · USUniversities UK · GBUniversity of Kentucky HealthCare · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MThe role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7MBIOMETRIC-GENETIC ANALYSIS OF CARDIOVASCULAR DISEASET32HL007567 · NHLBI · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ZHU, XIAOFENG · 1985 to 2021
$6.0MPilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7MComputer modeling of myosin binding protein C and its effects on cardiac contractionR01HL146676 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI Kenneth S Campbell, Julian Stelzer · 2019 to 2026
$4.3MFunctional consequences of FHC mutations in cardiac MyBPCR01HL114770 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STELZER, JULIAN · 2013 to 2023
$4.3MNRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9MMonomeric G-proteins and Cardioprotection from Heart FailureR01HL131782 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2017 to 2019
$1.6MGraduate Training in Integrative PhysiologyT32GM118292 · NIGMS · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S · 2017 to 2021
$999kMonomeric G-proteins and Cardioprotection from Heart FailureR56HL131782 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2016 to 2016
$525kNCATS NIH HHS TL1 TR002549NHLBI NIH HHS R01 HL114770NHLBI NIH HHS R01 HL131782NHLBI NIH HHS R01 HL146676NHLBI NIH HHS R56 HL131782NHLBI NIH HHS T32 HL007567NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P30 GM127211NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM118292
Abstract
Existing therapies to improve heart function target β-adrenergic receptor (β-AR) signaling and Ca
Indexed as
AnimalsCalciumCalcium Channels, L-TypeCalcium SignalingCardiomegalyGTP PhosphohydrolasesHeart FailureHumansMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyocardial ContractionMyocardiumMyocytes, Cardiacras ProteinsCalciumCalcium Channels, L-TypeGTP Phosphohydrolasesras ProteinsReceptors, Adrenergic, betaRrad protein, mouseSarcoplasmic Reticulum Calcium-Transporting ATPasescalcium channelcardiomyocytegene knockoutGTPaseheart failurepositive inotropeRGK GTPasetransgenic mice
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.