ReviewTrends in pharmacological sciences2019
Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.
Review in Trends in pharmacological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 2 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Effectiveness and analgesic effect of local infiltration analgesia and femoral nerve block after anterior cruciate ligament reconstruction: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial.BMC anesthesiology · 2025Trial
- Effects of computer-assisted cognitive behavioral therapy on anxiety in patients undergoing functional endoscopic sinus surgery: an exploratory fNIRS study of prefrontal hemodynamic functions.Frontiers in psychiatry · 2025Trial
- Comprehensive profiling of brain dynamics during anesthesia across phylogeny.Nature neuroscience · 2026Article
- Alchemical Free Energy Perturbation Predicts Relative Binding Affinities of Propofol Analogs and Etomidate Stereoisomers at the GABAACS omega · 2026Article
- Off-target effects of DREADD ligands revealed by an anesthesia emergence paradigm in mice.Cell reports methods · 2026Article
- Article
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Dynamic Electrocortical States and Paradoxical Complexity during Desflurane Anesthesia.Anesthesiology · 2026Article
- Pharmacokinetics and concentration-behavioral effect relationships differ between brain subcompartments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Genetic Assessment of Neurotoxicity Accompanied by Inhalational Anesthesia in Preclinical Studies with Focus on Sevoflurane and Isoflurane-A Narrative Review.Brain sciences · 2026Review
- Volatile anaesthetics modulate voltage-gated sodium channel function at a site directly linked to channel gating.Nature communications · 2026Article
- Are "GABAergic" Agents Really So Selective for GABA? Implications for Single- versus Multi-Site Hypotheses From Promiscuous Behavior of Anesthetics and Their Molecular Targets In Vitro.Anesthesia and analgesia · 2026Review
- Anesthetic State-Dependent Bidirectional Control of States of Consciousness via Heterogeneous Medial Septum to Ventral Tegmental Area Circuits under Sevoflurane in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Role of Dorsomedial Periaqueductal Gray Glutamatergic Neurons in Promoting Arousal under Multiple General Anesthetics in Mice.Anesthesiology · 2026Article
- Unbiased Segmentation and Multifeature Classification of Cortical Neuronal Activity Reveals Complex Dynamics Under Anesthesia.Neuroscience bulletin · 2026Article
- Targetable Effects of the Anesthetic, Ubiquinone-5, on Murine Cardiac Rhythm.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Electroencephalogram spectral power changes signalling the loss of volitional control induced by propofol: a secondary analysis of an observational study in spinal surgery patients.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Observational
- Reflections on Consciousness in Intensive Care.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Significant progress has been made in the 21st century towards a comprehensive understanding of the mechanisms of action of general anesthetics, coincident with progress in structural biology and molecular, cellular, and systems neuroscience. This review summarizes important new findings that include target identification through structural determination of anesthetic binding sites, details of receptors and ion channels involved in neurotransmission, and the critical roles of neuronal networks in anesthetic effects on memory and consciousness. These recent developments provide a comprehensive basis for conceptualizing pharmacological control of amnesia, unconsciousness, and immobility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.