ArticleJournal of autoimmunity2019
Obstetric and neonatal complications among women with autoimmune disease.
Article in Journal of autoimmunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Maternal and fetal outcomes in pregnant women with rheumatoid arthritis: a systematic review and meta-analysis.Clinical rheumatology · 2023Pooled it
- Pregnancy planning in women with rheumatic diseases: an integrated framework for risk stratification and multidisciplinary management.Rheumatology international · 2026Review
- Pregnancy characteristics in patients with autoimmune diseases with different onset times and their relationship with pregnancy outcomes.BMC pregnancy and childbirth · 2026Article
- Development and validation of machine learning models for predicting bronchopulmonary dysplasia risk in preterm neonates based on antenatal determinants: a retrospective cohort study.BMC pediatrics · 2025Article
- Inflamed Pathways to Motherhood: Evaluating Obstetric and Neonatal Outcomes in Rheumatic Pregnancies.Journal of clinical medicine · 2025Article
- Immune Dysregulation at the Maternal-Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model.Biomedicines · 2025Article
- Three-Dimensional Volume Ultrasound Assessment of Cesarean Scar Niche and Cervix in Pregnant Women: A Reproducibility Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Th17/Treg Cell Imbalance May Contribute to Spontaneous Preterm Labor.Journal of immunology research · 2025Review
- Female fertility preservation for family planning: a position statement of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).Journal of assisted reproduction and genetics · 2024Article
- Pregnancies in patients with systemic lupus erythematosus during 2000-2018 in Finland: a case-control study.Rheumatology international · 2024Article
- Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation.Scientific reports · 2023Article
- Adverse Perinatal Outcomes Before and After Diagnosis of Systemic Lupus Erythematosus Among African American Women.Arthritis care & research · 2022Article
- Developing and Validating Methods to Assemble Systemic Lupus Erythematosus Births in the Electronic Health Record.Arthritis care & research · 2022Article
- Pregnancy Outcome in Women With APECED (APS-1): A Multicenter Study on 43 Females With 83 Pregnancies.The Journal of clinical endocrinology and metabolism · 2022Article
- World Prematurity Day: it takes an NIH village to prevent preterm birth and improve treatments for preterm infants.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Prevalence of autoimmune conditions in pregnant women in a tertiary maternity hospital: A cross-sectional survey and maternity database review.Obstetric medicine · 2021Article
- Air pollution exposure and risk of adverse obstetric and neonatal outcomes among women with type 1 diabetes.Environmental research · 2021Article
- Maternal Morbidity and Mortality: Are We Getting to the "Heart" of the Matter?Journal of women's health (2002) · 2021Review
- Maternal and infant outcomes in sarcoidosis pregnancy: a Swedish population-based cohort study of first births.Respiratory research · 2020Article
- Family history of autoimmune disease in relation to time-to-pregnancy, pregnancy loss, and live birth rate.Journal of translational autoimmunity · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe impact of autoimmune diseases on pregnancy remains understudied on a population level. Examination of obstetric and neonatal outcomes among women with autoimmune disease and their infants can provide important insights for clinical management.
methodsAutoimmune diseases and outcomes were identified using medical records. Cesarean delivery, preterm birth, preeclampsia, small for gestational age (SGA), neonatal intensive care (NICU) admission, neonatal respiratory distress syndrome (RDS), and perinatal mortality risk was assessed. Poisson regression with robust standard errors estimated relative risks (RR) and 95% confidence intervals (95% CI) with adjustment for maternal characteristics and other chronic conditions.
resultsWomen with T1DM were at increased risk for nearly all outcomes including RDS (RR: 3.62; 95% CI: 2.84, 4.62), perinatal mortality (RR: 2.35; 95% CI: 1.12, 4.91), cesarean delivery (RR: 2.16; 95% CI: 2.02, 2.32) and preterm birth (RR: 3.52; 95% CI: 3.17, 3.91). Women with SLE also had higher risk for preterm delivery (RR: 2.90; 95% CI: 2.42, 3.48) and RDS (RR:2.99; 95% CI: 1.99, 4.51) as did women with Crohn's (cesarean delivery RR:1.31, 95% CI: 1.08, 1.60; preterm delivery RR: 1.84, 95% CI: 1.37, 2.49. RA increased risk for SGA (RR:1.66; 95% CI: 1.08, 2.55). CONCLUSION(S): Despite the heterogeneity in autoimmune diseases, we observed elevated preterm birth risk for most women with autoimmune disease. SLE and T1DM appeared to confer increased risk for a wide range of adverse outcomes.
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Registered trials
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