Evidence map›Paper›PMID 31147132›Full record

ArticleJournal of vascular surgery2019

Intraoperative contrast-enhanced ultrasound for early diagnosis of endoleaks during endovascular abdominal aortic aneurysm repair.

Claudio Bianchini Massoni, Paolo Perini, Mara Fanelli, Alessandro Ucci, Giulia Rossi, Matteo Azzarone, Tiziano Tecchio, Antonio Freyrie

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of vascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Utilization of intraoperative contrast-enhanced ultrasound in the treatment of complex endoleaks.Journal of vascular surgery cases and innovative techniques · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Claudio Bianchini MassoniDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy. Electronic address: claudiobianchinim@gmail.com.
Paolo PeriniDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
Mara FanelliDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
Alessandro UcciDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
Giulia RossiDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
Matteo AzzaroneDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
Tiziano TecchioDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
Antonio FreyrieDepartment of Medicine and Surgery, University Hospital of Parma, Parma, Italy.
University of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the feasibility and utility of intraoperative contrast-enhanced ultrasound (CEUS) for early detection of endoleaks (ELs) during endovascular abdominal aortic aneurysm repair (EVAR) compared with completion digital subtraction angiography.

methodsPatients undergoing elective EVAR from January 2017 to April 2018 were consecutively enrolled in this prospective study. After endograft deployment, two-digital subtraction angiography (2DSA) with orthogonal C-arm angulations (anteroposterior and sagittal view) were routinely performed. After the endovascular treatment of clear, high-flow type I/III ELs detected by 2DSA, intraoperative CEUS was carried out in sterile conditions on the surgical field before guidewire removal. Presence and type of EL were evaluated with 2DSA and CEUS. CEUS was performed with the vascular surgeon blinded to the 2DSA findings. The primary end point was the level of agreement between 2DSA and CEUS to detect any type of EL and type II EL. Agreement between two diagnostic methods was calculated using Cohen's kappa. The secondary end point was utility of CEUS for intraoperative adjunctive procedure guidance.

resultsSixty patients were enrolled (mean age, 78 ± 6 years; 90% male). 2DSA revealed 11 ELs (18%; 1 type IA, 10 type II), and CEUS 25 ELs (42%; 2 type IA, 23 type II). 2DSA and CEUS were in agreement in 39 cases (65%; 32 no ELs, 7 type II ELs). CEUS detected 17 ELs not identified by 2DSA (28%; 2 type IA, 15 type II); 2DSA detected three ELs not identified by CEUS (5%; 3 type II). In one case, 2DSA and CEUS detected type II and type IA ELs, respectively. For EL and type II EL detection, Cohen's kappa was 0.255 and 0.250, respectively (both "fair agreement"). Intraoperative adjunctive sac embolization was performed under CEUS control in 4 cases and technical success was 100%.

conclusionsIntraoperative CEUS during EVAR is feasible and can detect a greater number of ELs than 2DSA, in particular type II ELs. Further studies are necessary to assess the reliability of this intraoperative diagnostic examination. In type II ELs, CEUS may represent an additional, useful tool for intraoperative sac embolization guidance.

Indexed as

Contrast MediaEndovascular ProceduresAgedAged, 80 and overAngiography, Digital SubtractionAortic Aneurysm, AbdominalEarly DiagnosisEndoleakFeasibility StudiesFemaleHumansIntraoperative CareIntraoperative ComplicationsMaleProspective StudiesUltrasonographyContrast MediaAbdominalAngiographyAortic aneurysmContrast-enhanced ultrasoundDigital subtractionEndoleak

Identifiers

PMID31147132
OpenAlexW2947482665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.