Evidence map›Paper›PMID 31146872›Full record

ArticleJACC. Heart failure2019

Sex-Based Differences in Outcomes After Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network.

Gennaro Giustino, Jessica Overbey, Doris Taylor, Gorav Ailawadi, Katherine Kirkwood, Joseph DeRose, Marc A Gillinov, François Dagenais, Mary-Lou Mayer, Alan Moskowitz and 9 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00807040 (Evaluation of Outcomes Following Mitral Valve Repair/Replacement in Severe Chronic Ischemic Mitral Regurgitation), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00807040 phase2completednot on this map

Evaluation of Outcomes Following Mitral Valve Repair/Replacement in Severe Chronic Ischemic Mitral Regurgitation

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2008 to 2014Enrolled251ConditionsMitral Valve Insufficiency, Coronary Artery DiseaseArmsMitral Valve Repair with Annuloplasty, Mitral Valve Replacement
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  8. Identifying Responders to Transcatheter Interventions for Secondary Mitral Regurgitation.Current treatment options in cardiovascular medicine · 2025
    Review
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  17. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 2 countries.

Gennaro GiustinoThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Jessica OverbeyDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Doris TaylorDepartment of Regenerative Medicine Research, Texas Heart Institute, Houston, Texas.
Gorav AilawadiDivision of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia.
Katherine KirkwoodDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Joseph DeRoseDepartment of Cardiovascular and Thoracic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Marc A GillinovDepartment of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
François DagenaisInstitut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
Mary-Lou MayerDepartment of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Alan MoskowitzDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Emilia BagiellaDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Marissa MillerNational Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, Maryland.
Paul GrayburnDivision of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
Peter K SmithDivision of Cardiothoracic Surgery, Department of Surgery, Duke University, Durham, North Carolina.
Annetine GelijnsDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: Annetine.gelijns@mssm.edu.
Patrick O'GaraDivision of Cardiology, Brigham and Women's' Hospital, Boston, Massachusetts.
Michael AckerDepartment of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Anuradha LalaThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Judy HungDivision of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
Icahn School of Medicine at Mount Sinai · USMount Sinai Hospital · USUniversity of Pennsylvania · USAlbert Einstein College of Medicine · USBaylor University Medical Center · USBrigham and Women's Hospital · USCleveland Clinic · USDuke University · USInstitut universitaire de cardiologie et de pneumologie de Québec · CAMassachusetts General Hospital · USNational Institutes of Health · USUniversity of Virginia · US

Funding

REVISED CAROL ACT IIU01HL088942 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GELIJNS, ANNE CHRISTINE, MOSKOWITZ, ALAN J · 2007 to 2025
$122.6M
CIHRNHLBI NIH HHS U01 HL088942
6 · The paper itself

Abstract

objectivesThis study investigated sex-based differences in outcomes after mitral valve (MV) surgery for severe ischemic mitral regurgitation (SIMR).

backgroundWhether differences in outcomes exist between men and women after surgery for SIMR remains unknown.

methodsPatients enrolled in a randomized trial comparing MV replacement versus MV repair for SIMR were included and followed for 2 years. Endpoints for this analysis included all-cause mortality, major adverse cardiovascular and cerebrovascular events (MACCE) (defined as the composite of death, stroke, hospitalization for heart failure, worsening New York Heart Association functional class or MV re-operation), quality of life (QOL), functional status, and percentage of change in left ventricular end-systolic volume index (LVESVI) from baseline through 2 years.

resultsOf 251 patients enrolled in the trial, 96 (38.2%) were women. Compared with men, women had smaller LV volumes and effective regurgitant orifice areas (EROA) but greater EROA/left ventricular (LV) end-diastolic volume ratios. At 2 years, women had higher rates of all-cause mortality (27.1% vs. 17.4%, respectively; adjusted hazard ratio [adjHR]: 1.85; 95% confidence interval [CI]: 1.05 to 3.26; p = 0.03) and of MACCE (49.0% vs. 38.1%, respectively; adjHR: 1.58; 95% CI: 1.06 to 2.37; p = 0.02). Women also reported worse QOL and functional status at 2 years. There were no significant differences in the percentage of change over 2 years in LVESVI between women and men (adjβ: -10.4; 95% CI: -23.4 to 2.6; p = 0.12).

conclusionsWomen with SIMR displayed different echocardiographic features and experienced higher mortality and worse QOL after MV surgery than men. There were no significant differences in the degree of reverse LV remodeling between sexes. (Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation [Severe Ischemic Mitral Regurgitation]; NCT00807040).

Indexed as

Heart Valve Prosthesis ImplantationMitral Valve AnnuloplastyAgedCause of DeathDisease ProgressionFemaleHeart FailureHospitalizationHumansMaleMiddle AgedMitral Valve InsufficiencyMortalityMyocardial InfarctionMyocardial IschemiaQuality of Lifeischemic mitral regurgitationmitral valve repairmitral valve replacementwomen

Identifiers

PMID31146872
PMCPMC6676484
OpenAlexW2918536328

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.