ArticleBMC cancer2019
Risk of loco-regional recurrence and distant metastases of patients with invasive breast cancer up to ten years after diagnosis - results from a registry-based study from Germany.
Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Spare the Nipple: A Systematic Review of Tumor Nipple-Distance and Oncologic Outcomes in Nipple-Sparing Mastectomy.Annals of surgical oncology · 2023Pooled it
- Margin status and survival outcomes after breast cancer conservation surgery: prospectively registered systematic review and meta-analysis.BMJ (Clinical research ed.) · 2022Pooled it
- Real-world characteristics and invasive disease-free survival of resected patients with HR-positive/HER2-negative early breast cancer: evidence from German population-based cancer registries.ESMO real world data and digital oncology · 2026Article
- External validation of a data-driven algorithm to identify breast cancer recurrences from administrative healthcare data.Breast (Edinburgh, Scotland) · 2026Article
- Reassessing the Role of Regular Physical Examination in Post-treatment Breast Cancer Surveillance.Annals of surgical oncology · 2026Article
- Distant recurrence and margin involvement in invasive breast cancer.British journal of cancer · 2026Article
- Ethical navigation of biobanking establishment in Ukraine: learning from the experience of developing countries.Journal of medical ethics · 2026Article
- Recurrence Rate Following Breast Conservation Surgery: A Retrospective Cohort Study.The breast journal · 2026Article
- Article
- Validation of a Machine Learning Model for Predicting Postmastectomy Radiotherapy Recommendation Following Immediate Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- Recurrence Patterns in Breast Cancer: A Single-Center Retrospective Analysis.Journal of clinical medicine · 2025Article
- Long-Term Locoregional Outcomes in a Contemporary Cohort of Young Women With Breast Cancer.JAMA surgery · 2025Article
- Postoperative complications after breast cancer surgery and effect on recurrence and survival: population-based cohort study.BJS open · 2024Article
- Oncological outcomes in patients with residual triple-negative breast cancer after preoperative chemotherapy.Radiation oncology journal · 2024Article
- The Impact of Adjuvant Radiotherapy on Immediate Prepectoral Implant-Based Breast Reconstruction.Aesthetic plastic surgery · 2024Article
- Cancer-specific risk prediction with a serum microRNA signature.Cancer science · 2024Article
- Article
- FZD7-Targeted Nanoparticles to Enhance Doxorubicin Treatment of Triple-Negative Breast Cancer.ACS omega · 2024Article
- Alcohol, Smoking, and Risks of Breast Cancer Recurrence and Mortality among Women with Luminal, Triple-Negative, and HER2-Overexpressing Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation-based estimates of the long-term risk of loco-regional recurrence and distant metastases of breast cancer (BRC) patients are scant, as most published studies used hospital-based cohorts or participants of clinical trials. This work aims to extend available knowledge by providing population-based long-term estimates of the cumulative risk of BRC recurrence up to 10 years after diagnosis.
methodsData from the population-based Saarland Cancer Registry were used and included 9359 female patients with primary invasive BRC diagnosed between 1999 and 2009. Estimates of the cumulative incidence (CI) of BRC recurrence were derived for patients who had received local surgery with free resection margins by type of recurrence and stratified by age, tumor characteristics and major treatment options, taking into account mortality from any cause as a competing risk.
resultsThe 10-year CI of BRC recurrence was 16%. For loco-regional recurrence and distant metastases alone it was 8 and 11%, respectively. The estimates showed substantial variation and were particularly increased if tumors were advanced (T1/2N+ 23%, T3/4N0 24%, T3/4N+ 34%), of high grade (23%), or of 'HER2/neu positive' (28%) or 'triple negative' subtype (23%), respectively.
conclusionsThe derived estimates reflect the risk of 'real world' patients and may therefore extend available knowledge. These data are thus of great relevance for clinicians, their patients and researchers. The study likewise demonstrated the usefulness of cancer registries for a population-based monitoring of the effectiveness of cancer care in terms of disease recurrence as a major treatment related outcome measure.
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