Evidence map›Paper›PMID 31146654›Full record

ArticleJournal of neurotrauma2019

Restoring Ventilatory Control Using an Adaptive Bioelectronic System.

Ricardo Siu, James J Abbas, Brian K Hillen, Jefferson Gomes, Stefany Coxe, Jonathan Castelli, Sylvie Renaud, Ranu Jung

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ricardo SiuDepartment of Biomedical Engineering, Florida International University, Miami, Florida.
James J AbbasSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona.
Brian K HillenDepartment of Biomedical Engineering, Florida International University, Miami, Florida.
Jefferson GomesDepartment of Biomedical Engineering, Florida International University, Miami, Florida.
Stefany CoxeDepartment of Psychology, Florida International University, Miami, Florida.
Jonathan CastelliUniversité de Bordeaux, INP Bordeaux, IMS CNRS UMR 5218, Bordeaux, France.
Sylvie RenaudUniversité de Bordeaux, INP Bordeaux, IMS CNRS UMR 5218, Bordeaux, France.
Ranu JungDepartment of Biomedical Engineering, Florida International University, Miami, Florida.
Florida International University · USArizona State University · US

Funding

CRCNS: Computation-Enabled Adaptive Ventilatory Control SystemR01NS086088 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI JUNG, RANU · 2013 to 2015
$592k
NINDS NIH HHS R01 NS086088
6 · The paper itself

Abstract

Ventilatory pacing by electrical stimulation of the phrenic nerve or of the diaphragm has been shown to enhance quality of life compared to mechanical ventilation. However, commercially available ventilatory pacing devices require initial manual specification of stimulation parameters and frequent adjustment to achieve and maintain suitable ventilation over long periods of time. Here, we have developed an adaptive, closed-loop, neuromorphic, pattern-shaping controller capable of automatically determining a suitable stimulation pattern and adapting it to maintain a desired breath-volume profile on a breath-by-breath basis. The system adapts the pattern of stimulation parameters based on the error between the measured volume sampled every 40 ms and a desired breath volume profile.

Indexed as

AnimalsCervical VertebraeDiaphragmMalePhrenic NervePulmonary VentilationRatsRats, Sprague-DawleyRespiration, ArtificialSpinal Cord InjuriesTidal Volumeclosed-loopneuromorphicrespiratory pacingspinal cord injurystimulation

Identifiers

PMID31146654
PMCPMC6892433
OpenAlexW2949739392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.