ArticleJournal of behavioral addictions2019
Alterations in functional networks during cue-reactivity in Internet gaming disorder.
Article in Journal of behavioral addictions, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Neural mechanisms of behavioral addiction: An ALE meta-analysis and MACM analysis.Journal of behavioral addictions · 2025Pooled it
- Internet addiction-induced brain structure and function alterations: a systematic review and meta-analysis of voxel-based morphometry and resting-state functional connectivity studies.Brain imaging and behavior · 2023Pooled it
- Meta-analysis of structural and functional brain alterations in internet gaming disorder.Frontiers in psychiatry · 2022Pooled it
- Structural and Functional Brain Abnormalities in Internet Gaming Disorder and Attention-Deficit/Hyperactivity Disorder: A Comparative Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Predicting IGD treatment outcomes across interventions using a whole-brain functional connectome biomarker.Dialogues in clinical neuroscience · 2027Trial
- Light Therapy Alleviates Addiction-Related Symptoms and Reshapes Habenula and Midbrain Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Connectome-based predictive modelling of problematic gaming in youth from the ABCD study.Journal of behavioral addictions · 2026Article
- Predictive neural signature of internet gaming disorder severity revealed by cross-network connectivity.Psychoradiology · 2026Article
- Altered long-range visual hierarchical connectivity in internet gaming disorder: reduced V1-LOC connectivity and its association with addiction severity.Frontiers in psychiatry · 2026Article
- Mindfulness meditation reduces symptoms and modulates neural circuitry in comorbid internet gaming disorder and depression.PNAS nexus · 2025Article
- Neural Correlates of Resistance to Gaming Desire Induced by Social Media Content.Addiction biology · 2025Article
- Biomarkers of Internet Gaming Disorder-A Narrative Review.Journal of clinical medicine · 2024Review
- Ten years of research on the treatments of internet gaming disorder: A scoping review and directions for future research.Journal of behavioral addictions · 2024Article
- The Effect of Time Spent on Online Gaming on Problematic Game Use in Male: Moderating Effects of Loneliness, Living Alone, and Household Size.Psychiatry investigation · 2024Article
- Explicit and implicit effects of gaming content on social media on the behavior of young adults.Frontiers in psychology · 2024Article
- Functional connectivity changes in the brain of adolescents with internet addiction: A systematic literature review of imaging studies.PLOS mental health · 2024Article
- Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study.Frontiers in public health · 2024Article
- Independent component analysis for internet gaming disorder.Dialogues in clinical neuroscience · 2023Review
- Structural and Functional Neural Alterations in Internet Addiction: A Study Protocol for Systematic Review and Meta-Analysis.Psychiatry investigation · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCue-induced brain reactivity has been suggested to be a fundamental and important mechanism explaining the development, maintenance, and relapse of addiction, including Internet gaming disorder (IGD). Altered activity in addiction-related brain regions has been found during cue-reactivity in IGD using functional magnetic resonance imaging (fMRI), but less is known regarding the alterations of coordinated whole brain activity patterns in IGD.
methodsTo investigate the activity of temporally coherent, large-scale functional brain networks (FNs) during cue-reactivity in IGD, independent component analysis was applied to fMRI data from 29 male subjects with IGD and 23 matched healthy controls (HC) performing a cue-reactivity task involving Internet gaming stimuli (i.e., game cues) and general Internet surfing-related stimuli (i.e., control cues).
resultsFour FNs were identified that were related to the response to game cues relative to control cues and that showed altered engagement/disengagement in IGD compared with HC. These FNs included temporo-occipital and temporo-insula networks associated with sensory processing, a frontoparietal network involved in memory and executive functioning, and a dorsal-limbic network implicated in reward and motivation processing. Within IGD, game versus control engagement of the temporo-occipital and frontoparietal networks were positively correlated with IGD severity. Similarly, disengagement of temporo-insula network was negatively correlated with higher game-craving. DISCUSSION: These findings are consistent with altered cue-reactivity brain regions reported in substance-related addictions, providing evidence that IGD may represent a type of addiction. The identification of the networks might shed light on the mechanisms of the cue-induced craving and addictive Internet gaming behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.