Evidence map›Paper›PMID 31146471›Full record

ArticleCancers2019

Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells.

Olga Pastorino, Maria Teresa Gentile, Alessandro Mancini, Nunzio Del Gaudio, Antonella Di Costanzo, Adriana Bajetto, Paola Franco, Lucia Altucci, Tullio Florio, Maria Patrizia Stoppelli and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. International journal of molecular sciences · 2024
    Article
  7. Review
  8. Article
  9. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
    Review
  10. Heliyon · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Olga PastorinoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy. olga.pastorino@gmail.com.
Maria Teresa GentileDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy. mariateresa.gentile@unicampania.it.
Alessandro ManciniDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy. alessandro.mancini@unicampania.it.ORCID 0000-0002-3010-5925
Nunzio Del GaudioDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy. nunzio.delgaudio@unicampania.it.
Antonella Di CostanzoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy. antonella.dicostanzo@unicampania.it.
Adriana BajettoPharmacology Unit, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genova, Italy. adriana.bajetto@unige.it.
Paola FrancoInstitute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT), National Research Council of Italy, 80131 Naples, Italy. paola.franco@igb.cnr.it.
Lucia AltucciDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy. lucia.altucci@unicampania.it.
Tullio FlorioPharmacology Unit, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genova, Italy. tullio.florio@unige.it.ORCID 0000-0002-2394-996X
Maria Patrizia StoppelliInstitute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT), National Research Council of Italy, 80131 Naples, Italy. mpatrizia.stoppelli@igb.cnr.it.
Luca Colucci-D'AmatoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy. luca.colucci@unicampania.it.
University of Campania "Luigi Vanvitelli" · ITInstitute of Genetics and Biophysics · ITOspedale Policlinico San Martino · IT

Funding

AIRC 17217BioUp Sagl BioUp SaglFP7-BLUEPRINT 282510Lotta alle patologie concologiche iCUREPOR SATINPRIN 20152TE5PKprogetti retrospettivi progetto MERCURIO FESRRegione Campania FASE2-IDEALUniversità della Campania Luigi Vanvitelli progetto VALERE,
6 · The paper itself

Abstract

Glioblastoma (GBM), a high-grade glioma (WHO grade IV), is the most aggressive form of brain cancer. Available treatment options for GBM involve a combination of surgery, radiation and chemotherapy but result in a poor survival outcome. GBM is a high-vascularized tumor and antiangiogenic drugs are widely used in GBM therapy as adjuvants to control abnormal vasculature. Vasculogenic mimicry occurs in GBM as an alternative vascularization mechanism, providing a means whereby GBM can escape anti-angiogenic therapies. Here, using an in vitro tube formation assay on Matrigel

Indexed as

angiogenesiscancer stem cellscell invasioncell migrationglioblastomaHDACvasculogenic mimicry

Identifiers

PMID31146471
PMCPMC6627137
OpenAlexW2947392261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.