Evidence map›Paper›PMID 31146429›Full record

ArticleMolecules (Basel, Switzerland)2019

A Malonyl-Based Scaffold for Conjugatable Multivalent Carbohydrate-BODIPY Presentations.

Clara Uriel, Rebeca Sola-Llano, Jorge Bañuelos, Ana M Gomez, J Cristobal Lopez

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clara UrielInstituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. clara.uriel@csic.es.ORCID 0000-0003-4598-7438
Rebeca Sola-LlanoDepartamento Química Física, Universidad del País Vasco (UPV/EHU), Aptdo 644, 48080 Bilbao, Spain. rebeca.sola@ehu.es.ORCID 0000-0003-1998-3644
Jorge BañuelosDepartamento Química Física, Universidad del País Vasco (UPV/EHU), Aptdo 644, 48080 Bilbao, Spain. jorge.banuelos@ehu.es.ORCID 0000-0002-8444-4383
Ana M GomezInstituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. ana.gomez@csic.es.ORCID 0000-0002-8703-3360
J Cristobal LopezInstituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. jc.lopez@csic.es.ORCID 0000-0003-0370-4727

Funding

Govierno Vasco, Spain IT912-16Ministerio de Economia y Competitividad (MINECO) Spain CTQ2015-66702-RMinisterio de Economia y Competitividad (MINECO) Spain MAT2017-83856-C3-3-P
6 · The paper itself

Abstract

A concise synthetic route from methylmalonate to a tetravalent aliphatic scaffold has been developed. The ensuing tetra-tethered derivative is equipped with two hydroxyl groups, as well as orthogonal alkene and alkyne functionalities. The usefulness of the scaffold has been demonstrated with the preparation of two representative multivalent derivatives: (i) a tetravalent compound containing two D-mannose units, one fluorescent boron-dipyrromethene (BODIPY) dye and a suitably functionalized amino acid and (ii) by way of dimerization and saponification, a water-soluble tetramannan derivative containing two fluorescent BODIPY units. Additionally, photophysical measurements conducted on these derivatives support the viability of the herein designed single and double BODIPY-labeled carbohydrate-based clusters as fluorescent markers.

Indexed as

Boron CompoundsCarbohydratesChemistry Techniques, SyntheticMalonatesMolecular StructureSpectrum Analysis4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsCarbohydratesMalonatesBODIPYconjugationglycosylationmonosaccharidemultivalent presentationtetravalent scaffold

Identifiers

PMID31146429
PMCPMC6600552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.