Evidence map›Paper›PMID 31146394›Full record

ReviewAnimals : an open access journal from MDPI2019

A Review of the Actions of Endogenous and Exogenous Vasoactive Substances during the Estrous Cycle and Pregnancy in Rats.

Luisauris Jaimes, Raúl Vinet, Marcela Knox, Bernardo Morales, Julio Benites, Claudio Laurido, José L Martínez

Abstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Innervation of adipocytes is limited in mouse perivascular adipose tissue.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luisauris JaimesFaculty of Chemistry and Biology, University de Santiago de Chile, Estación Central 9160020, Chile. luisauris.jaimes@usach.cl.
Raúl VinetCMBi, Faculty of Pharmacy, Universidad de Valparaíso, Valparaíso 2360102, Chile. raul.vinet@uv.cl.
Marcela KnoxCMBi, Faculty of Pharmacy, Universidad de Valparaíso, Valparaíso 2360102, Chile. marcela.knox@gmail.com.
Bernardo MoralesFaculty of Chemistry and Biology, University de Santiago de Chile, Estación Central 9160020, Chile. bernardo.morales@usach.cl.
Julio BenitesFaculty of Health Science, Universidad Arturo Prat, Iquique 1100000, Chile. julio.benites@unap.cl.
Claudio LauridoFaculty of Chemistry and Biology, University de Santiago de Chile, Estación Central 9160020, Chile.
José L MartínezVice Chancellor of Investigation, Development and Innovation, Universidad de Santiago de Chile, Estación Central 9160020, Chile. joseluis.martinez@usach.cl.

Funding

Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de Chile No. 021643MS
6 · The paper itself

Abstract

Vascular endothelium plays a key role in regulating cardiovascular homeostasis by controlling the vascular tone. Variations in sex hormones during the reproductive cycle of females affect the homeostasis of the cardiovascular system. Also, the evidence shows that estrogens show a cardioprotective effect. On this basis, this study describes some vascular responses induced by vasoactive substances during the estrous cycle in rats. We obtained the information available on this topic from the online databases that included scientific articles published in the Web of Science, PubMed, and Scielo. Many investigations have evaluated the vasoactive response of substances such as acetylcholine and norepinephrine during the estrous cycle. In this review, we specifically described the vascular response to vasoactive substances in rats during the estrous cycle, pregnancy, and in ovariectomized rats. In addition, we discussed the existence of different signaling pathways that modulate vascular function. The knowledge of these effects is relevant for the optimization and development of new treatments for some vascular pathologies.

Indexed as

cardiovascular diseasesendothelial cellsendotheliumestrous cyclepregnancyvascular reactivityvasoactive substances

Identifiers

PMID31146394
PMCPMC6617363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.