Evidence map›Paper›PMID 31146200›Full record

ArticleThe International journal on drug policy2019

Street fentanyl use: Experiences, preferences, and concordance between self-reports and urine toxicology.

Raminta Daniulaityte, Robert R Carlson, Matthew P Juhascik, Kraig E Strayer, Ioana E Sizemore

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  9. Heroin or fentanyl: Prevalence of confirmed fentanyl in ED patients with suspected heroin overdose.Journal of the American College of Emergency Physicians open · 2024
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  12. Are you thinking what I'm thinking? Defining what we mean by "polysubstance use."The American journal of drug and alcohol abuse · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Raminta DaniulaityteCenter for Interventions, Treatment, and Addictions Research, Department of Population and Public Health Sciences, Boonshoft School of Medicine, Wright State University, 3171 Research Blvd, Kettering, OH 45420, United States. Electronic address: raminta.daniulaityte@wright.edu.
Robert R CarlsonCenter for Interventions, Treatment, and Addictions Research, Department of Population and Public Health Sciences, Boonshoft School of Medicine, Wright State University, 3171 Research Blvd, Kettering, OH 45420, United States. Electronic address: robert.carlson@wright.edu.
Matthew P JuhascikMontgomery County Coroner's Office/Miami Valley Regional Crime Lab (MCCO/MVRCL), 361 W Third St, Dayton, OH 45402, United States. Electronic address: juhascikm@mcohio.org.
Kraig E StrayerDepartment of Chemistry, Wright State University, 202 Oelman Hall, Dayton, OH 45435, United States. Electronic address: kraigstrayer10@gmail.com.
Ioana E SizemoreDepartment of Chemistry, Wright State University, 202 Oelman Hall, Dayton, OH 45435, United States. Electronic address: ioana.pavel@wright.edu.
Wright State University · USHamilton County Coroner · US

Funding

A Natural History Study of Buprenorphine Diversion, Self-Treatment, and Use of Drug Abuse Treatment ServicesR01DA040811 · NIDA · WRIGHT STATE UNIVERSITY · PI NAHHAS, RAMZI WILLIAM · 2016 to 2019
$2.2M
Characterizing fentanyl outbreaks: Ethnographic and forensic perspectivesR21DA042757 · NIDA · WRIGHT STATE UNIVERSITY · PI DANIULAITYTE, RAMINTA · 2016 to 2017
$408k
NIDA NIH HHS R01 DA040811NIDA NIH HHS R21 DA042757
6 · The paper itself

Abstract

backgroundConducted in Dayton, Ohio, the study aims to characterize user knowledge and experiences with non-pharmaceutical fentanyl-type drugs (NPFs) and compare self-reports with urine toxicology for NPFs and heroin.

methodsBetween May 2017-January 2018, 60 individuals who self-reported heroin/NPF use were interviewed using structured questionnaire on socio-demographics, NPF and other drug use practices. Unobserved urine samples were collected and analyzed using: 1) liquid-chromatography-tandem mass spectrometry (LC-MS/MS)-based method (Toxicology lab) to identify 34 fentanyl analogues, metabolites, and other synthetic opioids; 2) immunoassay-based method to screen for opiates (heroin). Sensitivity, specificity and Cohen's kappa were calculated to assess agreement between self-reports and urine toxicology.

resultsThe sample was 52% female, and over 90% white. Almost 60% reported preference for heroin, and 40% for NPF. Participants endorsed a number of ways of distinguishing heroin from NPF, including appearance (88.3%), effects (76.7%), taste (55%), and information provided by dealers (53.3%). Almost 80% felt confident they could distinguish heroin from NPF, but knowledge about fentanyl analogues was limited. LC-MS/MS testing identified 8 types of NPFs. Over 88% tested positive for NPFs, including 86% fentanyl, 48% carfentanil, 42% acetyl fentanyl. About 47% screened positive for opiates/heroin, and all of them were also positive for NPFs. When comparing self-reported use of NPF to urine toxicology, sensitivity and specificity were relatively high (84% and 83.3%, accordingly), while Cohen's Kappa was 0.445, indicating fair agreement. Sensitivity and specificity were lower for heroin (77.8% and 50.0%, accordingly), and Cohen's Kappa was 0.296, indicating low agreement between self-reports of heroin use and urine toxicology. DISCUSSION: Nearly 90% of the study participants tested positive for NPF-type drugs. Participants were more likely to over-report heroin use and underreport NPF use. The majority had little knowledge about fentanyl analogues. Study findings will inform development of novel harm reduction approaches to reduce overdose mortality.

Indexed as

Substance Abuse DetectionAdultChromatography, LiquidFemaleFentanylHealth Knowledge, Attitudes, PracticeHeroin DependenceHumansIllicit DrugsMaleMiddle AgedOhioOpioid-Related DisordersSelf ReportSensitivity and SpecificitySurveys and QuestionnairescarfentanilFentanylIllicit DrugsN-(1-phenethylpiperidin-4-yl)-N-phenylacetamideCarfentanilFentanylFentanyl analoguesHeroinNon-pharmaceutical fentanylNovel synthetic opioidsUrine toxicology

Identifiers

PMID31146200
PMCPMC6868314
OpenAlexW2947027702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.