ArticleDiabetes/metabolism research and reviews2019
Tale of two Indians: Heterogeneity in type 2 diabetes pathophysiology.
Article in Diabetes/metabolism research and reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Improved Detection of Abnormal Glucose Tolerance in Africans: The Value of Combining Hemoglobin ADiabetes care · 2020Trial
- The Soifua Manuia reference panel with 2,570 Samoan haplotypes improves genotype imputation quality among Samoans.Communications biology · 2026Article
- Impacting lives of people with diabetes: lessons learnt in India may be applicable to other low- and middle-income countries.Diabetologia · 2026Review
- Insulin deficiency is associated with early postpartum T2DM in Indian women with gestational diabetes.Frontiers in clinical diabetes and healthcare · 2026Article
- Lessons Learned From Epidemiology of Type 2 Diabetes in South Asians: Kelly West Award Lecture 2024.Diabetes care · 2025Article
- Review
- Article
- The prevalence of gestational diabetes among underweight and normal weight women worldwide: a scoping review.Frontiers in clinical diabetes and healthcare · 2024Article
- The burgeoning cardiovascular disease epidemic in Indians - perspectives on contextual factors and potential solutions.The Lancet regional health. Southeast Asia · 2023Review
- A Strategic Research Framework for Defeating Diabetes in India: A 21st-Century Agenda.Journal of the Indian Institute of Science · 2023Review
- Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus.International journal of molecular sciences · 2023Review
- The phenotype of type 1 diabetes in sub-Saharan Africa.Frontiers in public health · 2023Review
- Waist circumference and dysglycaemia: new insights and additional questions, but do not miss the opportunity to measure it!Internal and emergency medicine · 2022Article
- The impact of birthweight on subsequent phenotype of type 2 diabetes in later life.Diabetic medicine : a journal of the British Diabetic Association · 2022Article
- Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes.Diabetologia · 2022Article
- Non-invasive type 2 diabetes risk scores do not identify diabetes when the cause is β-cell failure: The Africans in America study.Frontiers in public health · 2022Article
- Impact of SARS-CoV-2 on Progression of Glycemic and Cardiometabolic Variables and Changes in Insulin Indices: A Longitudinal Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Beta-cell failure rather than insulin resistance is the major cause of abnormal glucose tolerance in Africans: insight from the Africans in America study.BMJ open diabetes research & care · 2021Observational
- Diabetes-related lower extremity complications in a multi-ethnic Asian population: a 10 year observational study in Singapore.Diabetologia · 2021Observational
- Lifestyle Interventions for Diabetes Prevention in South Asians: Current Evidence and Opportunities.Current diabetes reports · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
aimsType 2 diabetes is a heterogeneous disease and may manifest from multiple disease pathways. We examined insulin secretion and insulin resistance across two ethnicities with particularly high risk for diabetes yet with widely different distributions of weight class. MATERIALS AND
methodsIn this population-based, cross-sectional study, Pima Indians from Southwestern United States (n = 865) and Asian Indians from Chennai, India (n = 2374) had a 75-g oral glucose tolerance test. We analysed differences in plasma glucose, plasma insulin, insulin resistance (HOMA-IR), and insulin secretion (ΔI
resultsPima Indians were younger (mean 27.4 ± SD 6.6, Asian: 33.9 ± 6.7 years) and had higher BMI (33.6 ± 8.1, Asian: 25.7 ± 4.9 kg/m
conclusionsMetabolic differences between Pima and Asian Indians suggest heterogeneous pathways of type 2 diabetes in the early natural history of disease, with emphasis of insulin resistance in Pima Indians and emphasis of poor insulin secretion in Asian Indians.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.