ArticlePLoS computational biology2019
Close proximity interactions support transmission of ESBL-K. pneumoniae but not ESBL-E. coli in healthcare settings.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Prioritizing isolation precautions: a patient-centered approach to infection prevention and control.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Review
- Conference report of the 2024 Antimicrobial Resistance Meeting.npj antimicrobials and resistance · 2024Article
- Klebsiella pneumoniae, a human-dog shuttle organism for the genes of CTX-M ESBL.Scientific reports · 2024Article
- Healthcare as a driver, reservoir and amplifier of antimicrobial resistance: opportunities for interventions.Nature reviews. Microbiology · 2024Review
- One decade of point-prevalence surveys for carriage of extended-spectrum beta-lactamase-producing enterobacterales: whole genome sequencing based prevalence and genetic characterization in a large Dutch teaching hospital from 2013 to 2022.Antimicrobial resistance and infection control · 2024Article
- Using contact network dynamics to implement efficient interventions against pathogen spread in hospital settings: A modelling study.PLoS medicine · 2024Article
- Development of a prediction model for the acquisition of extended spectrum beta-lactam-resistant organisms in U.S. international travellers.Journal of travel medicine · 2023Article
- A one-year genomic investigation of Escherichia coli epidemiology and nosocomial spread at a large US healthcare network.Genome medicine · 2022Article
- Cost-effectiveness of strategies to control the spread of carbapenemase-producing Enterobacterales in hospitals: a modelling study.Antimicrobial resistance and infection control · 2022Article
- Risk factors for antibiotic resistance and mortality in patients with bloodstream infection of Escherichia coli.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Measuring close proximity interactions in summer camps during the COVID-19 pandemic.EPJ data science · 2022Article
- Impact of the COVID-19 pandemic on the surveillance of antimicrobial resistance.The Journal of hospital infection · 2021Article
- Article
- Reorganization of nurse scheduling reduces the risk of healthcare associated infections.Scientific reports · 2021Article
- Relevance of intra-hospital patient movements for the spread of healthcare-associated infections within hospitals - a mathematical modeling study.PLoS computational biology · 2021Article
- Long-Lasting Decrease of the Acquisition ofInternational journal of environmental research and public health · 2020Article
- Article
Corrections and comments
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic-resistance of hospital-acquired infections is a major public health issue. The worldwide emergence and diffusion of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, including Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP), is of particular concern. Preventing their nosocomial spread requires understanding their transmission. Using Close Proximity Interactions (CPIs), measured by wearable sensors, and weekly ESBL-EC-and ESBL-KP-carriage data, we traced their possible transmission paths among 329 patients in a 200-bed long-term care facility over 4 months. Based on phenotypically defined resistance profiles to 12 antibiotics only, new bacterial acquisitions were tracked. Extending a previously proposed statistical method, the CPI network's ability to support observed incident-colonization episodes of ESBL-EC and ESBL-KP was tested. Finally, mathematical modeling based on our findings assessed the effect of several infection-control measures. A potential infector was identified in the CPI network for 80% (16/20) of ESBL-KP acquisition episodes. The lengths of CPI paths between ESBL-KP incident cases and their potential infectors were shorter than predicted by chance (P = 0.02), indicating that CPI-network relationships were consistent with dissemination. Potential ESBL-EC infectors were identified for 54% (19/35) of the acquisitions, with longer-than-expected lengths of CPI paths. These contrasting results yielded differing impacts of infection control scenarios, with contact reduction interventions proving less effective for ESBL-EC than for ESBL-KP. These results highlight the widely variable transmission patterns among ESBL-producing Enterobacteriaceae species. CPI networks supported ESBL-KP, but not ESBL-EC spread. These outcomes could help design more specific surveillance and control strategies to prevent in-hospital Enterobacteriaceae dissemination.
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