Evidence map›Paper›PMID 31145609›Full record

ArticleInorganic chemistry2019

Murine Calprotectin Coordinates Mn(II) at a Hexahistidine Site with Ca(II)-Dependent Affinity.

Rose C Hadley, Derek M Gagnon, Andrew Ozarowski, R David Britt, Elizabeth M Nolan

Open access · greenAbstract read
In one paragraph

Article in Inorganic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. EPR characterization of a metal-binding site in RquA.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  2. Article
  3. Article
  4. Post-translational modifications on the metal-sequestering protein calprotectin.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  5. Steric Effects on the Chelation of MnChemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rose C HadleyDepartment of Chemistry , Massachusetts Institute of Technology (MIT) , Cambridge , Massachusetts 02139 , United States.
Derek M GagnonDepartment of Chemistry , University of California, Davis , Davis , California 95616 , United States.ORCID http://orcid.org/0000-0003-1737-6365
Andrew OzarowskiNational High Magnetic Field Laboratory , Florida State University , Tallahassee , Florida 32310 , United States.ORCID http://orcid.org/0000-0001-6225-9796
R David BrittDepartment of Chemistry , University of California, Davis , Davis , California 95616 , United States.ORCID http://orcid.org/0000-0003-0889-8436
Elizabeth M NolanDepartment of Chemistry , Massachusetts Institute of Technology (MIT) , Cambridge , Massachusetts 02139 , United States.ORCID http://orcid.org/0000-0002-6153-8803
Massachusetts Institute of Technology · USUniversity of California, Davis · USFlorida State University · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Bioinorganic Explorations of Host-Defense ProteinsR01GM118695 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NOLAN, ELIZABETH M · 2017 to 2025
$2.3M
NIEHS NIH HHS P30 ES002109NIGMS NIH HHS R01 GM118695NIGMS NIH HHS R35 GM126961
6 · The paper itself

Abstract

Manganese is an essential metal ion that bacterial pathogens need to acquire from the vertebrate host during infection. In the mammalian nutritional immunity strategy to combat bacterial infection, the host restricts bacterial access to Mn(II) by sequestering this metal nutrient using the protein calprotectin (CP). The role of murine calprotectin (mCP) in Mn(II) sequestration has been demonstrated in vivo, but the molecular basis of this function has not been evaluated. Herein, biochemical assays and electron paramagnetic resonance (EPR) spectroscopy are employed to characterize the Mn(II) binding properties of mCP. We report that mCP has one high-affinity Mn(II) binding site. This site is a His

Indexed as

AnimalsBinding SitesCalciumCoordination ComplexesHumansLeukocyte L1 Antigen ComplexManganeseMiceMolecular StructureCalciumCoordination ComplexesLeukocyte L1 Antigen ComplexManganese

Identifiers

PMID31145609
PMCPMC6803030
OpenAlexW2947357501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.