Evidence map›Paper›PMID 31145508›Full record

ReviewGlia2019

GABAergic-astrocyte signaling: A refinement of inhibitory brain networks.

Sara Mederos, Gertrudis Perea

Abstract readReview
In one paragraph

Review in Glia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  6. Review
  7. Article
  8. Astrocytes and Tinnitus.Brain sciences · 2024
    Review
  9. Article
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  11. Article
  12. Article
  13. Review
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  15. Article
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  19. Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sara MederosDepartment of Functional and Systems Neurobiology, Instituto Cajal, CSIC, Madrid, Spain.
Gertrudis PereaDepartment of Functional and Systems Neurobiology, Instituto Cajal, CSIC, Madrid, Spain.ORCID 0000-0001-5924-9175

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action of GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astrocytes as integral elements of synaptic transmission. However, GABAergic interneurons can also engage astrocyte signaling; therefore, it is tempting to speculate about different scenarios where, based on particular interneuron cell type, GABAergic-astrocyte interplay would be involved in diverse outcomes of brain function. In this review, we will highlight current data supporting the existence of dynamic GABAergic-astrocyte communication and its impact on the inhibitory-regulated brain responses, bringing new perspectives on the ways astrocytes might contribute to efficient neuronal coding.

Indexed as

AnimalsAstrocytesBrainGABAergic Neuronsgamma-Aminobutyric AcidInterneuronsNeural InhibitionSynaptic Transmissiongamma-Aminobutyric Acidastrocyteexcitation/inhibition balanceGABAergic interneuronsgliotransmissionsynaptic plasticity

Identifiers

PMID31145508
PMCPMC6772151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.