Evidence map›Paper›PMID 31145335›Full record

ArticleMedicine2019

The alteration of ferritin and transferrin saturation under body mass index and blood pressure in first-time and regular male blood donors in Taiwan.

Hsuan-Hui Wang, Li-Na Liao, Ci-Wen Chang, Yu-Chang Chang, Kang-Hsi Wu, Jiunn-Liang Ko

Open access · goldAbstract read
In one paragraph

Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Hsuan-Hui WangTaichung Blood Center, Taiwan Blood Services Foundation.
Li-Na LiaoSchool of Medicine, College of Medicine, China Medical University.
Ci-Wen ChangDepartment of Laboratory Medicine, China Medical University Hospital.
Yu-Chang ChangDepartment of Laboratory Medicine, China Medical University Hospital.
Kang-Hsi WuDivision of Pediatric Hematology/Oncology, Children's Hospital.
Jiunn-Liang KoInstitute of Medicine, Chung Shan Medical University.
China Medical University · CNChung Shan Medical University · TWChildren's Hospital · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron status, body mass index (BMI) and blood pressure (BP) are all important health indicators. In this study, ferritin and transferrin saturation levels and their correlations with BMI and BP were investigated in first-time and regular male blood donors in Taiwan. Serum ferritin and transferrin saturation values represented iron status of blood donors. Serum ferritin, serum iron, and total iron binding capacity (TIBC) were determined by chemiluminescent immunoassay sandwich method, timed-endpoint method, and turbidimetric method, respectively. Transferrin saturation was calculated as 100× serum iron/TIBC. Statistical analyses included 2-sample t test, chi-square test, Pearson correlation coefficient, and multiple linear regression. Comparisons of ferritin and transferrin saturation mean values with BMI, age, systolic blood pressure (SBP), diastolic blood pressure (DBP), and occupation were conducted. A total of 111 first-time donors and 1249 regular blood donors participated in this study. The ferritin and transferrin saturation mean values of regular male blood donors were lower than those of first-time male blood donors, but remained within the safe range. BMI was positively correlated with serum log ferritin, but not with transferrin saturation value in first-time and regular blood donors. First-time donors with BMI ≥24 kg/m and aged more than 40 years demonstrated 1.37-fold higher serum ferritin on average. Among regular donors, significant effects of BMI ≥24 kg/m and age >40 years were observed with 1.25- and 1.18-fold higher serum ferritin levels, respectively. First-time donors with SBP ≥120/DBP ≥80, ≥120/<80, and <120/≥80 mm Hg had on average 1.65-, 1.54-, and 2.59-fold higher serum ferritin levels than those with normal BP. Ferritin level was higher in BMI ≥24 kg/m subgroup than in BMI <24 kg/m subgroup among first time and regular male donors, but no difference was found in transferrin saturation values.Abnormal SBP/DBP was associated with increased ferritin level only in first-time male blood donors.

Indexed as

Blood PressureBody Mass IndexAdultBlood DonorsFerritinsHumansLinear ModelsMaleMiddle AgedTaiwanTime FactorsTransferrinFerritinsTransferrin

Identifiers

PMID31145335
PMCPMC6709272
OpenAlexW2948002160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.