Evidence map›Paper›PMID 31145215›Full record

Trial reportPain2019

Recovery of physical activity after cesarean delivery and its relationship with pain.

Emily E Sharpe, Jessica L Booth, Timothy T Houle, Peter H Pan, Lynnette C Harris, Carol A Aschenbrenner, James C Eisenach

2 registry-linked trialsOpen access · greenAbstract readClinical Trial
In one paragraph

Trial report in Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06704490 recruitingnot on this mapstarted 2024, after this paper: background citation

Analysis of the Incidence and Risk Factors of Chronic Pain After Cesarean Section

TypeobservationalSponsorHuazhong University of Science and TechnologyRan2024 to 2026Enrolled600ConditionsPostoperative Pain, Cesarean Section SurgeryArmsCesarean section
NCT06716359 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Comparison of the Effects of Hydromorphone and Nalbuphine Patient Controlled Analgesia in Postoperative Pain After Cesarean Section

TypeobservationalSponsorHuazhong University of Science and TechnologyRan2024 to 2025Enrolled240ConditionsPostoperative Pain, Patiet Controlled AnalgesiaArmsObservational study without intervention
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Emily E SharpeDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States.
Jessica L BoothDepartment of Anesthesiology, University of Colorado Health in Colorado Springs, Colorado Springs, CO, United States.
Timothy T HouleDepartment of Anesthesiology and Perioperative Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Peter H PanDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Lynnette C HarrisDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Carol A AschenbrennerDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
James C EisenachDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Wake Forest University · USHarvard University · USMayo Clinic in Arizona · USUniversity of Colorado Colorado Springs · US

Funding

WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
Role of Stress-induced LC Dysfunction on Pain Trajectory and Disability after SurgeryP01GM113852 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI EISENACH, JAMES, HOULE, TIMOTHY T · 2016 to 2021
$8.0M
Receptor Selective Spinal AnalgesiaR37GM048085 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI EISENACH, JAMES · 2011 to 2020
$3.7M
NCRR NIH HHS M01 RR007122NIGMS NIH HHS P01 GM113852NIGMS NIH HHS R37 GM048085
6 · The paper itself

Abstract

Pain and physical activity are tightly intertwined. Although their relationship has been explored in chronic pain conditions, we know little about the pattern of recovery in activity and its short- and long-term relationship with pain after surgery. We recruited 103 women undergoing elective cesarean delivery and acquired daily pain assessments and hourly steps in 98 of them for 2 months after surgery. Compliance was good, with 78% of subjects missing less than 7 days of activity. Study personnel required daily checking for compliance and 20 minutes per subject per week in study. Activity increased over the first 2 postoperative months in a log(time) manner. The slope of each modeled individual curve for activity was inversely correlated (r = -0.54; P < 0.0001) with worst daily pain. After removing these 2-month trends, pain and activity within an individual day were negatively associated with each point increase in pain being inversely associated with -119 steps (95% confidence interval [CI] = -214 to -25; P = 0.013). A patient's previous experience of pain was not associated with current activity as well as current activity was not associated with future pain scores. These data, although limited by the study of a single operation in a unique social circumstance with low risk of chronic postsurgical pain, demonstrate feasibility of measuring hourly activity for 2 months after surgery. Recovery from pain and inactivity are tightly correlated, and the negative relationship between within-day pain and activity without interday carryover relationships is in stark contrast to findings in chronic pain conditions.

Indexed as

AccelerometryAdultCesarean SectionExerciseFeasibility StudiesFemaleHumansPain MeasurementPostoperative PainPregnancyProspective StudiesRecovery of Function

Identifiers

PMID31145215
PMCPMC6768712
OpenAlexW2947789634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.