Evidence map›Paper›PMID 31145154›Full record

ReviewCurrent opinion in organ transplantation2019

The future of HIV Organ Policy Equity Act is now: the state of HIV+ to HIV+ kidney transplantation in the United States.

Brian J Boyarsky, Mary Grace Bowring, Ashton A Shaffer, Dorry L Segev, Christine M Durand

Abstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Observational
  11. Donor evaluation in the era of HIV-positive organ transplantation: The importance of the infectious diseases specialist.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  12. Barriers to kidney transplant evaluation in HIV-positive patients with advanced kidney disease: A single-center study.Transplant infectious disease : an official journal of the Transplantation Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brian J BoyarskyDepartment of Surgery, Johns Hopkins University School of Medicine.
Mary Grace BowringDepartment of Surgery, Johns Hopkins University School of Medicine.
Ashton A ShafferDepartment of Surgery, Johns Hopkins University School of Medicine.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine.
Christine M DurandDepartment of Medicine, Johns Hopkins University School of Medicine.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
HOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Optimal Antiretroviral Therapy During Bone Marrow Transplant in HIV-1 InfectionK23CA177321 · NCI · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2014 to 2018
$808k
HOPE in Action: HIV-to-HIV Solid Organ Transplantation in the USR34AI123023 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2016 to 2016
$243k
Understanding the Impact of HIV on Survival in End-Stage Liver DiseaseF30DK116658 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SHAFFER, ASHTON A · 2017 to 2019
$149k
Aggressive Organ Procurement Organization Report Cards to Safely Increase Kidney TransplantationF32DK124941 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BOYARSKY, BRIAN · 2020 to 2020
$81k
NCI NIH HHS K23 CA177321NIAID NIH HHS P30 AI094189NIAID NIH HHS R34 AI123023NIAID NIH HHS U01 AI134591NIDDK NIH HHS F30 DK116658NIDDK NIH HHS F32 DK124941NIDDK NIH HHS K24 DK101828NIGMS NIH HHS T32 GM007309
6 · The paper itself

Abstract

purpose of reviewWe report the current state of HIV+ to HIV+ kidney transplantation in the United States and remaining challenges in implementing this practice nationally. RECENT

findingsThe HIV Organ Policy Equity (HOPE) Act, which was the first step in unlocking the potential of HIV+ organ donors, mandates clinical research on HIV+ to HIV+ transplantation. As of March 2019, there have been 57 HOPE donors, including both true and false positive HOPE donors resulting in more than 120 transplants. SUMMARY: The HOPE Act, signed in 2013, reversed the federal ban on the transplantation of organs from HIV+ donors into HIV+ recipients. Ongoing national studies are exploring the safety, feasibility, and efficacy of both kidney and liver transplantation in this population. If successfully and fully implemented, HIV+ to HIV+ transplantation could attenuate the organ shortage for everyone waiting, resulting in a far-reaching public health impact.

Indexed as

HumansKidney TransplantationTissue and Organ ProcurementUnited States

Identifiers

PMID31145154
PMCPMC8713473

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.