Evidence map›Paper›PMID 31144984›Full record

ArticleAmerican journal of respiratory cell and molecular biology2019

Microbiota Contribute to Obesity-related Increases in the Pulmonary Response to Ozone.

Hiroki Tashiro, Youngji Cho, David I Kasahara, Jeffrey D Brand, Lynn Bry, Vladimir Yeliseyev, Galeb Abu-Ali, Curtis Huttenhower, Stephanie A Shore

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Obesity: Next game changer of allergic airway diseases?Clinical and translational medicine · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Obesity-related asthma and its relationship with microbiota.Frontiers in cellular and infection microbiology · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Obesity may enhance the adverse effects of NOThe Journal of allergy and clinical immunology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hiroki TashiroDepartment of Environmental Health and.
Youngji ChoDepartment of Environmental Health and.
David I KasaharaDepartment of Environmental Health and.
Jeffrey D BrandDepartment of Environmental Health and.
Lynn BryMassachusetts Host Microbiome Center, Brigham and Women's Hospital, Boston, Massachusetts; and.
Vladimir YeliseyevMassachusetts Host Microbiome Center, Brigham and Women's Hospital, Boston, Massachusetts; and.
Galeb Abu-AliDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Curtis HuttenhowerDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Stephanie A ShoreDepartment of Environmental Health and.
Brigham and Women's Hospital · USBroad Institute · USHarvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Impact of Obesity on Airway Responses to Air PollutionR01ES013307 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SHORE, STEPHANIE A · 2005 to 2019
$5.2M
Obesity and asthma: microbiome-metabolome interactionsR21ES024032 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHORE, STEPHANIE A · 2015 to 2016
$444k
NHLBI NIH HHS T32 HL007118NIDDK NIH HHS P30 DK034854NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES013307NIEHS NIH HHS R21 ES024032
6 · The paper itself

Abstract

Obesity is a risk factor for asthma, especially nonatopic asthma, and attenuates the efficacy of standard asthma therapeutics. Obesity also augments pulmonary responses to ozone, a nonatopic asthma trigger. The purpose of this study was to determine whether obesity-related alterations in gut microbiota contribute to these augmented responses to ozone. Ozone-induced increases in airway responsiveness, a canonical feature of asthma, were greater in obese

Indexed as

Airway ResistanceAnimalsAnti-Bacterial AgentsAsthmaCelluloseDietary FiberFecal Microbiota TransplantationFemaleFermentationGastrointestinal MicrobiomeGerm-Free LifeMiceMice, Inbred C57BLMice, ObeseObesityOzoneAnti-Bacterial AgentsCelluloseDietary Fiberleptin receptor, mouseOzonePectinsReceptors, Leptinairway responsivenessdietary fibergut microbiomeneutrophilobesity

Identifiers

PMID31144984
PMCPMC6890400
OpenAlexW2947279719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.