Evidence map›Paper›PMID 31144830›Full record

ArticleNeuropsychology2019

Trauma-related psychiatric and behavioral conditions are uniquely associated with sustained attention dysfunction.

Michael Esterman, Francesca C Fortenbaugh, Meghan E Pierce, Jennifer R Fonda, Joseph DeGutis, William Milberg, Regina McGlinchey

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Moderated mediation for exercise maintenance in pain and posttraumatic stress disorder: A randomized trial.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020
    Trial
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  9. Association of mild traumatic brain injury, post-traumatic stress disorder, and other comorbidities on photosensitivity.Optometry and vision science : official publication of the American Academy of Optometry · 2024
    Article
  10. Review
  11. Poorer Inhibitory Control Uniquely Contributes to Greater Functional Disability in Post-9/11 Veterans.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023
    Article
  12. The functional relevance of visuospatial processing speed across the lifespan.Cognitive research: principles and implications · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael EstermanTranslational Research Center for TBI and Stress Disorders.ORCID 0000-0002-9000-3920
Francesca C FortenbaughTranslational Research Center for TBI and Stress Disorders.
Meghan E PierceTranslational Research Center for TBI and Stress Disorders.
Jennifer R FondaTranslational Research Center for TBI and Stress Disorders.
Joseph DeGutisTranslational Research Center for TBI and Stress Disorders.
William MilbergTranslational Research Center for TBI and Stress Disorders.
Regina McGlincheyTranslational Research Center for TBI and Stress Disorders.
Center for Translational Molecular Medicine · NL

Funding

Stuart T. Hauser Research Training Program in Biological and Social Psychiatry.T32MH016259 · NIMH · JUDGE BAKER CHILDREN'S CENTER · PI Marek Kubicki, Martha E. Shenton · 1985 to 2026
$8.4M
Neurobiological & Clinical Phenotypes in OEF/OIF/OND Veterans with mTBI or BlastR21AT009430 · NCCIH · HARVARD MEDICAL SCHOOL · PI MILBERG, WILLIAM P · 2016 to 2017
$356k
Defining biotypes of PTSD with resting-state connectivityI01CX001653 · VA · VA BOSTON HEALTH CARE SYSTEM · PI ESTERMAN, MICHAEL · 2018 to 2021
–
Neural Mechanisms of Attention in PTSD and Comorbid TBIIK2CX000706 · VA · VA BOSTON HEALTH CARE SYSTEM · PI ESTERMAN, MICHAEL · 2014 to 2018
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Web-based Visual and Cognitive Screening Battery for Rural OEF/OIF/OND VeteransIK2RX002268 · VA · VA BOSTON HEALTH CARE SYSTEM · PI FORTENBAUGH, FRANCESCA COWDEN · 2018 to 2023
–
CSRD VA I01 CX001327CSRD VA I01 CX001653CSRD VA IK2 CX000706National Institutes of Health; NCCIHNCCIH NIH HHS R21 AT009430NIMH NIH HHS T32 MH016259ORD VA B9254-CRRD VA IK2 RX002268US Department of Veterans Affairs; Clinical Sciences Research and DevelopmentUS Department of Veterans Affairs; Rehabilitation Research and DevelopmentUS Department of Veterans Affairs; Rehabilitation Research and Development National Network Center for TBI ResearchUS Department of Veterans Affairs; Translational Research Center for TBI and Stress Disorders (TRACTS)
6 · The paper itself

Abstract

objectiveIt is increasingly recognized that trauma victims, particularly Veterans, have co-occurring psychological and physical conditions that impact cognition, especially the domains of sustained attention and executive functioning. Although previous work has generally attempted to isolate the unique cognitive effects of common combat-related comorbidities, less work has been done to examine how these conditions co-occur, and whether unique cognitive signatures accompany certain clinical combinations.

methodTo address this gap, we examined how several deployment-related conditions were associated with performance on a well-validated measure of sustained attention (i.e., gradual onset continuous performance task [gradCPT]) and a battery of standard neuropsychological measures in 123 Veterans from the Translational Research Center for TBI and Stress Disorders. Initially, a Principal component analysis was conducted to investigate how comorbid conditions grouped together.

resultsSeveral sustained attention measures from the gradCPT were differentially associated with four unique combinations of trauma-related pathology. Specifically, a somatic component representing the combination of current pain, sleep disturbance, and mild traumatic brain injury was associated with a higher rate of failures of attentional engagement. On the other hand, a comorbid posttraumatic stress disorder (PTSD) and mood disorder component (moodPTSD), as well as a substance use disorder component, were associated with higher rates of inhibitory control failures. Increased attentional instability was associated with moodPTSD as well as an anxiety disorder component. In contrast, the cognitive effects of deployment-related trauma were not observed on standard neuropsychological measures.

conclusionThese findings suggest that unique combinations of trauma-related pathology have dissociable effects on sustained attentional control. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Indexed as

VeteransAdultAnxiety DisordersAttentionBrain ConcussionCognitive DysfunctionCombat DisordersComorbidityExecutive FunctionFemaleHumansMaleMiddle AgedMood DisordersNeuropsychological TestsStress Disorders, Post-Traumatic

Identifiers

PMID31144830
PMCPMC6912598
OpenAlexW2947361683

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.