ArticleMolecular genetics & genomic medicine2019
Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis.
Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Circular RNAs in Endometriosis: from Expression Pattern To Pathogenesis.Cell biochemistry and biophysics · 2026Review
- Circular RNAs in endometriosis analyzed through RNA sequencing and bioinformatics for expression profile.PeerJ · 2025Article
- Expression Profiling of Coding and Noncoding RNAs in the Endometrium of Patients with Endometriosis.International journal of molecular sciences · 2024Article
- RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface.BMC women's health · 2022Article
- Article
- Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.Annals of medicine · 2021Article
- Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.Molecular and cellular biochemistry · 2021Article
- Translational Applications of Linear and Circular Long Noncoding RNAs in Endometriosis.International journal of molecular sciences · 2021Review
- Expression Analysis of Circular RNAs in Young and Sexually Mature Boar Testes.Animals : an open access journal from MDPI · 2021Article
- Melatonin levels and microRNA (miRNA) relative expression profile in the follicular ambient microenvironment in patients undergoing in vitro fertilization process.Journal of assisted reproduction and genetics · 2021Article
- Novel circRNA discovery in sheep shows evidence of high backsplice junction conservation.Scientific reports · 2021Article
- Current and Future Roles of Circular RNAs in Normal and Pathological Endometrium.Frontiers in endocrinology · 2021Review
- Elevated Circular RNA PVT1 Promotes Eutopic Endometrial Cell Proliferation and Invasion of Adenomyosis via miR-145/Talin1 Axis.BioMed research international · 2021Article
- Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model.Drug design, development and therapy · 2021Article
- Estrogen-decreased hsa_circ_0001649 promotes stromal cell invasion in endometriosis.Reproduction (Cambridge, England) · 2020Article
- CircATRNL1 promotes epithelial-mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro.Cell death & disease · 2020Article
- miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.Cell cycle (Georgetown, Tex.) · 2020Article
- A Novel Serum Exosomes-Based Biomarker hsa_circ_0002130 Facilitates Osimertinib-Resistance in Non-Small Cell Lung Cancer by Sponging miR-498.OncoTargets and therapy · 2020Article
- Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis.Molecular genetics & genomic medicine · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCircular RNAs (circRNAs) with miRNA response elements (MREs) could function as competing endogenous RNA (ceRNA) in regulating gene expression, thus playing vital roles in pathogenesis and progression of many diseases. However, the function of circRNAs in endometriosis remains unknown. This study was carried to profile the expression patterns of circRNAs in ovarian endometriosis.
methodsHigh throughput RNA-Seq was performed in six paired ectopic and eutopic endometrium tissues (ecEM vs. euEM), followed by quantitative real-time polymerase chain reaction (qRT-PCR) in 30 paired samples. Through bioinformatics prediction, we constructed a circRNA-miRNA -mRNA network and elucidated circRNAs functions by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses.
resultsA total of 146 upregulated and 148 downregulated circRNAs were identified, binding with 2,495 MREs. The qRT-PCR validation results of four upregulated circRNAs matched the RNA-Seq data. The ceRNA network included 48 miRNAs and 296 mRNAs. Functional analysis revealed several important pathways such as MAPK signaling pathway, and PI3K-AKT signaling pathway, which might be associated with the pathogenesis and development of endometriosis.
conclusionOur data suggested that circRNAs are differentially expressed in endometriosis, which might be candidate factors for pathogenesis of this disease and be considered as promising therapeutic targets in the future.
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