Evidence map›Paper›PMID 31144274›Full record

ArticleNeurocritical care2019

Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations.

Sherry H-Y Chou, R Loch Macdonald, Emanuela Keller, Unruptured Intracranial Aneurysms and SAH CDE Project Investigators

Open access · bronzeAbstract readConsensus Development Conference, NIH
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Spontaneous subarachnoid haemorrhage.Lancet (London, England) · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  17. Article
  18. Neuroprotective Strategies in Aneurysmal Subarachnoid Hemorrhage (aSAH).International journal of molecular sciences · 2021
    Review
  19. Interleukin 6 and Aneurysmal Subarachnoid Hemorrhage. A Narrative Review.International journal of molecular sciences · 2021
    Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sherry H-Y ChouDepartments of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh School of Medicine, 3550 Terrace Street Suite 646, Pittsburgh, PA, 15261, USA. chouh@upmc.edu.ORCID http://orcid.org/0000-0003-0548-9936
R Loch MacdonaldDivision of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
Emanuela KellerNeurocritical Care Unit, Department of Neurosurgery, UniversitätsSpital Zürich, Zurich, Switzerland.
Unruptured Intracranial Aneurysms and SAH CDE Project Investigators
St. Michael's Hospital · CAUniversity of Pittsburgh · US

Funding

Biomarkers of Vasospasm and Outcome following Subarachnoid HemorrhageK23NS073806 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHOU, SHERRY HSIANG-YI · 2011 to 2015
$940k
MicroRNA Endotypes of Systemic Inflammation in Sub-Arachnoid hemorrhaGE (MESSAGE)R21NS113037 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHOU, SHERRY HSIANG-YI · 2019 to 2019
$390k
CHI Baylor St Luke's Medical Center N/AMedical Research Council G1002605Neurocritical Care Society N/ANIDA NIH HHS HHSN271201200034CNINDS NIH HHS HHSN271201200034CNINDS NIH HHS K23 NS073806NINDS NIH HHS R21 NS113037
6 · The paper itself

Abstract

introductionDevelopment of clinical biomarkers to guide therapy is an important unmet need in aneurysmal subarachnoid hemorrhage (SAH). A wide spectrum of plausible biomarkers has been reported for SAH, but none have been validated due to significant variabilities in study design, methodology, laboratory techniques, and outcome endpoints.

methodsA systematic review of SAH biomarkers was performed per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The panel's recommendations focused on harmonization of (1) target cellular and molecular biomarkers for future investigation in SAH, (2) standardization of best-practice procedures in biospecimen and biomarker studies, and (3) experimental method reporting requirements to facilitate meta-analyses and future validation of putative biomarkers.

resultsNo cellular or molecular biomarker has been validated for inclusion as "core" recommendation. Fifty-four studies met inclusion criteria and generated 33 supplemental and emerging biomarker targets. Core recommendations include best-practice protocols for biospecimen collection and handling as well as standardized reporting guidelines to capture the heterogeneity and variabilities in experimental methodologies and biomarker analyses platforms.

conclusionSignificant variabilities in study design, methodology, laboratory techniques, and outcome endpoints exist in SAH biomarker studies and present significant barriers toward validation and translation of putative biomarkers to clinical use. Adaptation of common data elements, recommended biospecimen protocols, and reporting guidelines will reduce heterogeneity and facilitate future meta-analyses and development of validated clinical biomarkers in SAH.

Indexed as

Common Data ElementsAneurysm, RupturedBiomarkersBiomedical ResearchBrain IschemiaHumansIntracranial AneurysmMicrodialysisMortalityNational Institute of Neurological Disorders and Stroke (U.S.)National Library of Medicine (U.S.)PrognosisSpecimen HandlingSubarachnoid HemorrhageUnited StatesVasospasm, IntracranialBiomarkersApolipoprotein EBiomarkersBiospecimensB-type natriuretic peptide, common data elementsCardiac troponin ICerebrospinal fluidPlasma-type gelsolinS100βStandard operating procedureSubarachnoid hemorrhageTumor necrosis factor alpha, interleukin-6, metalloproteinase-9

Identifiers

PMID31144274
PMCPMC7888262
OpenAlexW2946956306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.