Evidence map›Paper›PMID 31144192›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2020

Impact of Radial Margin Status After Esophagectomy for Adenocarcinoma.

Leonidas Tapias, Luis F Tapias, Philicia Moonsamy, Michael Lanuti, Henning A Gaissert, Cameron D Wright, Ashok Muniappan, Douglas J Mathisen, Christopher R Morse

Abstract read
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In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Leonidas TapiasDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0003-4014-0924
Luis F TapiasDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.
Philicia MoonsamyDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.
Michael LanutiDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.
Henning A GaissertDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.
Cameron D WrightDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.
Ashok MuniappanDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.
Douglas J MathisenDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA.
Christopher R MorseDivision of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Founders 7, Boston, MA, 02114, USA. crmorse@partners.org.
Massachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe clinical impact of a positive radial margin after esophagectomy for cancer has not been clearly  identified. The goal of this study was to identify risk factors for a positive radial margin and determine the impact on recurrence and survival.

methodsRetrospective review of 196 patients with pathological T3 N0-3 esophageal adenocarcinoma undergoing esophagectomy between 2002 and 2017. Mortality data was extracted from Electronic Medical Records and Social Security Death Index.

resultsMean age was 63.7 ± 11.4 years, and there were 166 (84.7%) men. Neoadjuvant therapy was given in 141(71.9%) patients. We identified 29(14.8%) patients with a positive radial margin. Factors significantly associated with a positive radial margin include not receiving neoadjuvant therapy and presence of lymphatic, vascular, or perineural invasion. Overall, there were 94(48%) recurrences during a mean follow-up of 24.7 months. Involvement of the radial margin was not significantly associated with recurrence-free survival (HR 1.24, CI 95% 0.73-2.12, p = 0.425). Overall survival for the entire cohort was 41.6% and 28.9% at 3 and 5 years, respectively. Involvement of the radial margin did not have a significant impact on overall survival (HR 1.23, CI 95% 0.68-2.22, p = 0.493).

conclusionsThe likelihood of encountering a positive margin is associated with lack of neoadjuvant treatment and the presence of lymphatic, vascular, or perineural invasion in the esophagectomy specimen. An involved radial margin after esophagectomy for locally advanced cancer was not associated with tumor recurrence or overall survival in our cohort, and other factors such as lymph node involvement are stronger in determining outcome.

Indexed as

AdenocarcinomaEsophageal NeoplasmsAgedEsophagectomyHumansMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesEsophageal cancerRadial marginsRecurrenceSurvival

Identifiers

PMID31144192
OpenAlexW2947143721

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.