ArticleChinese journal of integrative medicine2019
Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats.
Article in Chinese journal of integrative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 29 citations in OpenAlex.
- Regulation of appetite-related neuropeptides by Panax ginseng: A novel approach for obesity treatment.Journal of ginseng research · 2022Review
- Neuronal mechanisms of ginseng on antiobesity effects: implication of its synergistic benefits with physical exercise.Journal of exercise rehabilitation · 2021Review
- Pharmacological activities of ginsenoside Rg5 (Review).Experimental and therapeutic medicine · 2021Review
- High-fat diet-induced memory impairment and anxiety-like behavior in rats attenuated by peel extract ofMetabolism open · 2021Article
- Gut Microbiota: Novel Therapeutic Target of Ginsenosides for the Treatment of Obesity and Its Complications.Frontiers in pharmacology · 2021Review
- Article
- Effect ofFrontiers in pharmacology · 2020Review
- Berberine for Appetite Suppressant and Prevention of Obesity.BioMed research international · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
objectiveTo examine the anti-obesity effects of ginsenosides in Korea Red Ginseng (KRG, Panax ginseng) in rats fed with a high-fat diet (HFD).
methodsTwenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks; subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re (10 mg/kg, intraperitoneal injection) for a further 3 weeks (n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide (NO) expression, leptin, neuropeptide Y (NPY), cholecystokinin (CCK) in the brains were measured.
resultsIn the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats (P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight (P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group (P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group (P<0.05).
conclusionPD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.
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