ArticleEuropean radiology2019
Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Early detection of white matter hyperintensities using SHIVA-WMH detector.Human brain mapping · 2024Article
- Topologic Efficiency Abnormalities of the Connectome in Asymptomatic Patients with Leukoaraiosis.Brain sciences · 2022Article
- Article
- The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities.Frontiers in aging neuroscience · 2021Article
- Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity.Frontiers in aging neuroscience · 2021Article
- White-matter hyperintensities in patients with carotid artery stenosis: An exploratory connectometry study.The neuroradiology journal · 2020Article
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Authors and funding
10 authors.
Funding
Abstract
objectivesAlthough white matter hyperintensities (WMHs) are quite commonly found incidentally, their aetiology, structural characteristics, and functional consequences are not entirely known. The purpose of this study was to quantify WMHs in a sample of young, neurologically asymptomatic adults and evaluate the structural and functional correlations of lesion load with changes in brain volume, diffusivity, and functional connectivity.
methodsMRI brain scan using multimodal protocol was performed in 60 neurologically asymptomatic volunteers (21 men, 39 women, mean age 34.5 years). WMHs were manually segmented in 3D FLAIR images and counted automatically. The number and volume of WMHs were correlated with brain volume, resting-state functional MRI (rs-fMRI), and diffusion tensor imaging (DTI) data. Diffusion parameters measured within WMHs and normally appearing white matter (NAWM) were compared.
resultsAt least 1 lesion was found in 40 (67%) subjects, median incidence was 1 lesion (interquartile range [IQR] = 4.5), and median volume was 86.82 (IQR = 227.23) mm
conclusionsWMHs are commonly found even in young, neurologically asymptomatic adults. Their presence is not associated with brain atrophy or global changes of diffusivity, but the increasing number and volume of these lesions correlate with changes of brain connectivity, and especially that of the cerebellum. KEY POINTS: • White matter hyperintensities (WMHs) are commonly found in young, neurologically asymptomatic adults. • The presence of WMHs is not associated with brain atrophy or global changes of white matter diffusivity. • The increasing number and volume of WMHs correlate with changes of brain connectivity, and especially with that of the cerebellum.
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