Observational studyClinical research in cardiology : official journal of the German Cardiac Society2020
Atrial high-rate episodes and risk of major adverse cardiovascular events in patients with cardiac implantable electronic devices.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Characteristics of patients with atrial high rate episodes detected by implanted defibrillator and resynchronization devices.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Trial
- Article
- Relationship Between Left Atrial Coupling Index and Atrial High-Rate Episodes.Pacing and clinical electrophysiology : PACE · 2025Article
- Association of P-wave characteristics with long-standing atrial high rate episodes (AHREs) following pacemaker implantation.BMC cardiovascular disorders · 2025Article
- New-Onset Device-Detected Atrial Fibrillation in Patients With Atrial Floating Dipole Implantable Cardioverter-Defibrillators: A Propensity Score-Matched Comparison With Conventional Dual-Chamber Systems.Journal of cardiovascular electrophysiology · 2025Article
- Monocyte/High-Density Lipoprotein Ratio Is Associated with Atrial High-Rate Episodes within One Year Detected by Cardiac Implantable Electronic Devices.Brazilian journal of cardiovascular surgery · 2023Article
- Oral Anticoagulation in Patients With Atrial High-Rate Episodes: Focus on Clinical Implications.Cureus · 2023Article
- The influence of atrial high-rate episodes on stroke and cardiovascular death: an update.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Atrial high-rate episodes intensify RScientific reports · 2023Article
- How should I treat patients with subclinical atrial fibrillation and atrial high-rate episodes? Current evidence and clinical importance.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Review
- Atrial Fibrillation in the Setting of Acute Pneumonia: Not a Secondary Arrhythmia.Reviews in cardiovascular medicine · 2022Review
- The Differential Prognostic Impact of Long-Duration Atrial High-Rate Episodes Detected by Cardiac Implantable Electronic Devices between Patients with and without a History of Atrial Fibrillation.Journal of clinical medicine · 2022Article
- Artificial intelligence predicts clinically relevant atrial high-rate episodes in patients with cardiac implantable electronic devices.Scientific reports · 2022Observational
- Atrial high-rate episodes predict major adverse cardio/cerebrovascular events in patients with cardiac implantable electrical devices.Scientific reports · 2021Observational
- Prevalence and predictors of subclinical atrial fibrillation in hospitalized older adults.Aging · 2021Article
- Remote monitoring and telemedicine in heart failure: implementation and benefits.Current cardiology reports · 2021Review
- Identifying At-Risk Patients for Sustained Atrial High-Rate Episodes Using the CJournal of the American Heart Association · 2021Article
- Atrial high‑rate episodes and risk of major adverse cardiovascular events in patients with dual chamber permanent pacemakers: a retrospective study.Scientific reports · 2021Article
- A Review of Biomarkers for Ischemic Stroke Evaluation in Patients With Non-valvular Atrial Fibrillation.Frontiers in cardiovascular medicine · 2021Review
- HATCH Score and Left Atrial Size Predict Atrial High-Rate Episodes in Patients With Cardiac Implantable Electronic Devices.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with atrial high-rate episodes (AHREs) are at higher risk of thromboembolic events and mortality. The risk of major adverse cardiovascular events (MACE) in these patients is unknown.
objectiveTo investigate the risk of MACE in patients implanted with cardiac implantable electronic devices (CIEDs) developing AHREs METHODS AND
resultsWe included 852 consecutive patients undergoing CIEDs implantation. Primary outcome was a composite endpoint of MACEs occurring after AHREs ≥ 5 min. AHRE was defined as > 175 bpm and lasting ≥ 5 min. We also performed a subgroup analysis in patients with the longest AHRE lasting ≥ 24 h. Cox regression analysis with time-dependent covariates was used to investigate the relationship between AHREs and MACEs. Mean age was 70.0 ± 13.6 years, and 39.3% were women: 325 patients developed AHREs ≥ 5 min [incidence rate (IR) 13.1% year 95% confidence interval (CI) 11.7-14.6] and 124 patients developed AHREs ≥ 24 h (IR 3.7%/year 95% CI 3.1-4.5). During a median follow-up of 37.0 months (IQR 19.0-64.3, 316,132 patient-years), 152 MACEs occurred (IR 4.85%/year, 95% CI 4.11-5.68). The IR of MACE occurring after AHREs onset was higher in patients developing AHREs ≥ 24 h (IR 1.13%/year) than AHREs ≥ 5 min (IR 0.63%/year, p = 0.030). Multivariable Cox regression analysis showed that AHREs ≥ 5 min (HR 1.788, 95% CI 1.247-2.562, p = 0.002), diabetes (HR 1.909, 95% CI 1.358-2.683, p < 0.001), heart failure (HR 2.203, 95% CI 1.527-3.178, p < 0.001), and coronary artery disease (HR 1.862, 95% CI 1.293-2.681, p = 0.001) were associated to MACE. This association was even stronger for AHREs ≥ 24 h (HR 2.390, 95% CI 1.481-3.857, p < 0.001).
conclusionsPatients implanted with CIEDs developing AHREs show a significant risk for MACE, which is dependent on AHREs burden. Cardiovascular prevention strategies in this patient population are warranted.
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